| Effect of Butea monosperma Lam. leaves and bark extracts on blood glucose in streptozotocin-induced severely diabetic rats. | |
| | |
MedLine Citation:
|
PMID: 22224059 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
BACKGROUND: Diabetes mellitus is a chronic metabolic disorder that has significant impact on the health, quality of life and life expectancy, as well as on the health care system. Butea monosperma Lam. Kuntze (Fabaceae), commonly known as palash, is widely used in the treatment of various diseases and disorders including diabetes. MATERIALS AND METHODS: The present study was planned to evaluate the antidiabetic effect of aqueous extracts of B. monosperma leaves and bark in streptozotocin-induced severely diabetic rats. The animals were divided into four groups, with each consisting of six rats, viz. control, diabetic control, leaf extract-treated and bark extract-treated groups. Treatment was continued for 6 weeks. The biochemical estimations included blood glucose and serum insulin levels. Histopathology of pancreas was also performed. RESULTS: The results indicated that both leaf and bark extracts of B. monosperma produced insignificant antihyperglycemic activity. The leaf and bark extracts reduced blood glucose to an extent of 28% and 11%, respectively. It was also evidenced that both leaf and bark extracts did not increase insulin synthesis or secretion and did not improve pancreatic architecture as reflected by the histopathologic studies. CONCLUSIONS: The findings of the study emphasize that B. monosperma does not possess significant antidiabetic activity in severe experimental diabetes at the dosage tested. |
| | |
Authors:
|
Faiyaz Ahmed; N S Siddaraju; M Harish; Asna Urooj |
Related Documents
:
|
7417389 - The validity of assessing changes in intestinal absorption mechanisms for dietary sugar... 15971409 - Dietary fructose: implications for dysregulation of energy homeostasis and lipid/carboh... 21146889 - Impact of dose adjustment for normal eating in australia (ozdafne) on subjective wellbe... 6377829 - Extrapancreatic effects of a sulphonylurea. decrease in xylose absorption by glipizide ... 3011579 - Evidence for abnormal cholinergic neuromuscular transmission in diabetic rat small inte... 21209519 - Diabetes mellitus: a review of its associations with different environmental factors. 6457859 - Defective suppressor cell generation in juvenile onset diabetes. 7028589 - Development of glucose intolerance and impaired plasma insulin response to glucose in o... 10672449 - The cost-effectiveness of different management strategies for type i diabetes: a swiss ... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Pharmacognosy research Volume: 4 ISSN: 0974-8490 ISO Abbreviation: Pharmacognosy Res Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-01-06 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101558769 Medline TA: Pharmacognosy Res Country: India |
Other Details:
|
Languages: eng Pagination: 33-6 Citation Subset: - |
Affiliation:
|
Department of Studies in Food Science and Nutrition, University of Mysore, Manasagangothri, Mysore, Karnataka, India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Dichlorvos and lindane induced oxidative stress in rat brain: Protective effects of ginger.
Next Document: Antibacterial activity and the histopathological study of crude extracts and isolated tecomine from ...