Document Detail

Effect of bisphosphonates on the progression of degenerative aortic stenosis.
MedLine Citation:
PMID:  20678125     Owner:  NLM     Status:  In-Data-Review    
Bisphosphonates appear to regulate mineralization in both bone and vasculature. Degenerative aortic stenosis (AS) is thought to be due to vascular calcification. We studied the effect of bisphosphonates on the progression of degenerative AS. A retrospective study was performed on patients >70 years, who had transthoracic echocardiograms (TTE) >1 year apart and an initial aortic valve area (AVA) of 0.6-2.0 cm(2) . Patients were excluded if they had an ejection fraction <40%, other significant valvular or congenital heart disease, end-stage renal disease or heart transplant. The cohort was divided depending on the use of bisphosphonates. Data were obtained by review of the TTE reports. AVA, peak and mean aortic valve gradient (AVG), and the change between the studies were calculated. Of 4,270 patients screened for AS, 76 patients fit study criteria with 8 in the bisphosphonate group and 68 in the nonbisphosphonate group. The period between the TTEs was 23 ± 5 months in both the groups. AVA in the nonbisphosphonate group worsened by 0.2 cm(2) and in the bisphosphonate group it improved by 0.1 cm(2) (P = 0.001 vs. nonbisphosphonate). The changes in peak and mean AVG between groups and compared to baseline were not significant. Bisphosphonates show promise for slowing the progression of degenerative AS. (Echocardiography 2011;28:1-7).
Antony Leslie Innasimuthu; William E Katz
Related Documents :
11082365 - Quality of life after aortic valve replacement at the age of >80 years.
8611985 - Aprotinin use with hypothermic circulatory arrest for aortic valve and thoracic aortic ...
18291145 - The ross procedure in infants and young children.
15063255 - Left heart bypass during descending thoracic aortic aneurysm repair does not reduce the...
1728885 - Complications of percutaneous endoscopic gastrostomy in head and neck cancer patients.
21727175 - Comparison of use of minimized cardiopulmonary bypass with conventional techniques on t...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Echocardiography (Mount Kisco, N.Y.)     Volume:  28     ISSN:  1540-8175     ISO Abbreviation:  Echocardiography     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8511187     Medline TA:  Echocardiography     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
Copyright Information:
© 2010, Wiley Periodicals, Inc.
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Deciphering the mysteries of crisscross heart by transthoracic echocardiography.
Next Document:  A Case of an Anomalous Superior Vena Cava with Anomalous Pulmonary Veins-When Two Wrongs Do not Make...