Document Detail

Effect of bioactive glasses on angiogenesis: a review of in vitro and in vivo evidences.
MedLine Citation:
PMID:  19831556     Owner:  NLM     Status:  MEDLINE    
The incorporation of bioactive glass into bone tissue-engineered scaffolds can be widely beneficial based on emerging evidence in the literature about the angiogenic potential of this material, particularly 45S5 Bioglass((R)). This article reviews the literature discussing in vitro studies which have demonstrated that increases in angiogenic indicators have been achieved through both direct and indirect contact of relevant cells with 45S5 Bioglass((R)) particles or with their dissolution products. A few available in vivo studies confirming the ability of bioactive glass, incorporated into scaffolds, to stimulate neovascularization are also discussed. Suggestions for further research are given, highlighting the need for specific investigations designed to assess the effect of particular ion dissolution products from bioactive glasses and their relative concentration on angiogenesis both in vitro and in vivo.
Alejandro A Gorustovich; Judith A Roether; Aldo R Boccaccini
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Review    
Journal Detail:
Title:  Tissue engineering. Part B, Reviews     Volume:  16     ISSN:  1937-3376     ISO Abbreviation:  Tissue Eng Part B Rev     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-06     Completed Date:  2010-06-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101466660     Medline TA:  Tissue Eng Part B Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  199-207     Citation Subset:  IM    
Research Laboratory, National Atomic Energy Commission (CNEA-Reg. Noroeste), Salta, Argentina.
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MeSH Terms
Angiogenesis Inducing Agents / metabolism
Biocompatible Materials / pharmacology
Cell Proliferation / drug effects
Cells, Cultured
Ceramics / pharmacology*
Endothelial Cells / drug effects,  metabolism,  physiology
Fibroblasts / drug effects,  metabolism,  physiology
Models, Animal
Neovascularization, Physiologic / drug effects*,  physiology
Reg. No./Substance:
0/Angiogenesis Inducing Agents; 0/Biocompatible Materials; 0/Bioglass; 0/Ceramics

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