| Effect of Beta-Alanine and Carnosine Supplementation on Muscle Contractility in Mice. | |
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MedLine Citation:
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PMID: 22895378 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: Enhanced carnosine levels have been shown to be ergogenic for high-intensity exercise performances, although the role of carnosine in the control of muscle function is poorly understood. Therefore, the aim of this study was to investigate the effect of long-term supplementation with increasing doses of carnosine and beta-alanine on muscle carnosine, anserine and taurine levels and on in vitro contractility and fatigue in mice. METHODS: Male NMRI mice (n = 66) were control fed or supplemented with either carnosine (0.1%, 0.5% or 1.8%) or beta-alanine (0.6 or 1.2%) in their drinking water for 8-12 weeks. Soleus and extensor digitorum longus (= EDL) were tested for in vitro contractile properties and carnosine, anserine and taurine content was measured in EDL and tibialis anterior by means of HPLC. RESULTS: Only supplementation with 1.8% carnosine and 1.2% beta-alanine resulted in markedly higher carnosine (up to +160%) and anserine levels (up to +46%) compared to control mice. Beta-alanine supplementation (1.2%) resulted in increased fatigue resistance in the beginning of the fatigue protocol in soleus (+2-4%) and a marked leftward shift of the force-frequency relation in EDL (10-31% higher relative forces). CONCLUSIONS: Comparable to humans, beta-alanine availability seems to be the rate-limiting step for synthesis of muscle histidine-containing dipeptides (HCD) in mice. Moreover, muscle HCD loading in mice moderately and muscle-dependently affects excitation-contraction coupling and fatigue. |
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Authors:
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Inge Everaert; Sanne Stegen; Bert Vanheel; Youri Taes; Wim Derave |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-14 |
Journal Detail:
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Title: Medicine and science in sports and exercise Volume: - ISSN: 1530-0315 ISO Abbreviation: Med Sci Sports Exerc Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-8-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8005433 Medline TA: Med Sci Sports Exerc Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Department of Movement and Sport Sciences, Ghent University, Ghent, Belgium 2Department of Basic Medical Sciences, division Physiology, Ghent University, Ghent, Belgium 3Department of Endocrinology, Ghent University Hospital, Ghent, Belgium. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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