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Effect of Beta-Alanine and Carnosine Supplementation on Muscle Contractility in Mice.
MedLine Citation:
PMID:  22895378     Owner:  NLM     Status:  Publisher    
PURPOSE: Enhanced carnosine levels have been shown to be ergogenic for high-intensity exercise performances, although the role of carnosine in the control of muscle function is poorly understood. Therefore, the aim of this study was to investigate the effect of long-term supplementation with increasing doses of carnosine and beta-alanine on muscle carnosine, anserine and taurine levels and on in vitro contractility and fatigue in mice. METHODS: Male NMRI mice (n = 66) were control fed or supplemented with either carnosine (0.1%, 0.5% or 1.8%) or beta-alanine (0.6 or 1.2%) in their drinking water for 8-12 weeks. Soleus and extensor digitorum longus (= EDL) were tested for in vitro contractile properties and carnosine, anserine and taurine content was measured in EDL and tibialis anterior by means of HPLC. RESULTS: Only supplementation with 1.8% carnosine and 1.2% beta-alanine resulted in markedly higher carnosine (up to +160%) and anserine levels (up to +46%) compared to control mice. Beta-alanine supplementation (1.2%) resulted in increased fatigue resistance in the beginning of the fatigue protocol in soleus (+2-4%) and a marked leftward shift of the force-frequency relation in EDL (10-31% higher relative forces). CONCLUSIONS: Comparable to humans, beta-alanine availability seems to be the rate-limiting step for synthesis of muscle histidine-containing dipeptides (HCD) in mice. Moreover, muscle HCD loading in mice moderately and muscle-dependently affects excitation-contraction coupling and fatigue.
Inge Everaert; Sanne Stegen; Bert Vanheel; Youri Taes; Wim Derave
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-14
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  -     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1Department of Movement and Sport Sciences, Ghent University, Ghent, Belgium 2Department of Basic Medical Sciences, division Physiology, Ghent University, Ghent, Belgium 3Department of Endocrinology, Ghent University Hospital, Ghent, Belgium.
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