Document Detail


Effect of Beta-Alanine and Carnosine Supplementation on Muscle Contractility in Mice.
MedLine Citation:
PMID:  22895378     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: Enhanced carnosine levels have been shown to be ergogenic for high-intensity exercise performances, although the role of carnosine in the control of muscle function is poorly understood. Therefore, the aim of this study was to investigate the effect of long-term supplementation with increasing doses of carnosine and beta-alanine on muscle carnosine, anserine and taurine levels and on in vitro contractility and fatigue in mice. METHODS: Male NMRI mice (n = 66) were control fed or supplemented with either carnosine (0.1%, 0.5% or 1.8%) or beta-alanine (0.6 or 1.2%) in their drinking water for 8-12 weeks. Soleus and extensor digitorum longus (= EDL) were tested for in vitro contractile properties and carnosine, anserine and taurine content was measured in EDL and tibialis anterior by means of HPLC. RESULTS: Only supplementation with 1.8% carnosine and 1.2% beta-alanine resulted in markedly higher carnosine (up to +160%) and anserine levels (up to +46%) compared to control mice. Beta-alanine supplementation (1.2%) resulted in increased fatigue resistance in the beginning of the fatigue protocol in soleus (+2-4%) and a marked leftward shift of the force-frequency relation in EDL (10-31% higher relative forces). CONCLUSIONS: Comparable to humans, beta-alanine availability seems to be the rate-limiting step for synthesis of muscle histidine-containing dipeptides (HCD) in mice. Moreover, muscle HCD loading in mice moderately and muscle-dependently affects excitation-contraction coupling and fatigue.
Authors:
Inge Everaert; Sanne Stegen; Bert Vanheel; Youri Taes; Wim Derave
Related Documents :
22760068 - In vitro measurements of tracheal constriction using mice.
7136818 - Reflex control of cat extrinsic and intrinsic tongue muscles exerted by intraoral recep...
12966248 - Reconstruction of an inner layer defect of the upper eyelid with avulsion of the superi...
22345428 - Emg activity in hyoid muscles during pig suckling.
3197398 - Changes in myoglobin and lactate dehydrogenase in muscle tissues of a diving bird, the ...
19593418 - Ankle bracing and the neuromuscular factors influencing joint stiffness.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-14
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  -     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1Department of Movement and Sport Sciences, Ghent University, Ghent, Belgium 2Department of Basic Medical Sciences, division Physiology, Ghent University, Ghent, Belgium 3Department of Endocrinology, Ghent University Hospital, Ghent, Belgium.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effects of Exercise Sessions on DXA Measurements of Body Composition in Active People.
Next Document:  Health Benefits of Physical Activity during Pregnancy: An International Perspective.