Document Detail

Effect of beam hardening on arterial enhancement in thoracoabdominal CT angiography with increasing patient size: an in vitro and in vivo study.
MedLine Citation:
PMID:  20656839     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To assess the effect of beam hardening on arterial enhancement in thoracoabdominal computed tomographic (CT) angiography in various body sizes in a phantom and in a clinical study. MATERIALS AND METHODS: An abdominal aortic phantom was placed in three cylindrical water containers simulating a small, an intermediate, and a large patient (diameters of 22, 30, and 40 cm, respectively). CT scanning was performed at 80, 100, and 120 kVp, and aortic attenuation was assessed. In a HIPAA-compliant institutional review board-approved study with waiver of informed consent, thoracoabdominal aortic attenuation was assessed in 100 consecutive patients (75 men, 25 women; mean body weight (BW), 79 kg) undergoing thoracoabdominal 64-section CT angiography at 80 kVp. Overall aortic attenuation in patients grouped according to BW (small patients [n = 26], <70 kg; intermediate patients [n = 41], 70-85 kg; large patients [n = 33], >85 kg) was compared. Overall aortic attenuation was correlated with BW, height, body mass index (BMI), body surface area (BSA), and lateral diameter by using linear regression. RESULTS: Comparison of the intermediate- and large-phantom groups relative to the small-phantom group indicated that mean aortic attenuation decreased by 9.7% and 13.4% at 80 kVp, 9.8% and 15.1% at 100 kVp, and 13.8% and 23.8% at 120 kVp, respectively (P < .001). In the clinical study, the overall aortic attenuation decreased by 11.3% and 20.0% in the intermediate- and large-patient groups relative to the small-patient group, respectively (P < .05). Overall aortic attenuation correlated well with BSA (R = -0.454), height (R = -0.421), and BW (R = -0.414), followed by lateral diameter (R = -0.291) and BMI (R = -0.211). CONCLUSION: Beam hardening may substantially contribute to reduced arterial enhancement in larger patients undergoing thoracoabdominal CT angiography. The beam-hardening effect on arterial enhancement is more pronounced at higher tube voltages.
Sebastian T Schindera; Isabelle Tock; Daniele Marin; Rendon C Nelson; Rainer Raupach; Marc Hagemeister; Gabriel von Allmen; Peter Vock; Zsolt Szucs-Farkas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Radiology     Volume:  256     ISSN:  1527-1315     ISO Abbreviation:  Radiology     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-26     Completed Date:  2010-09-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  528-35     Citation Subset:  AIM; IM    
Institute of Diagnostic, Interventional and Pediatric Radiology, University Hospital Berne, University of Berne, Freiburgstrasse 10, CH-3010 Berne, Switzerland.
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MeSH Terms
Aged, 80 and over
Angiography / instrumentation,  methods*
Aortic Aneurysm / physiopathology*,  radiography*
Aortography / methods*
Body Size*
Middle Aged
Phantoms, Imaging
Radiographic Image Enhancement / methods*
Radiography, Abdominal / methods
Radiography, Thoracic / methods
Reproducibility of Results
Sensitivity and Specificity
Thorax / physiopathology
Tomography, X-Ray Computed / instrumentation,  methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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