Document Detail

Effect of BW443C81, a novel opioid, on non-cholinergic bronchoconstrictor responses and neurogenic plasma extravasation in the guinea pig.
MedLine Citation:
PMID:  1414685     Owner:  NLM     Status:  MEDLINE    
The novel, peripherally acting opioid peptide, BW443C81, which attenuates airway sensory nerve impulses, was examined on non-cholinergic (NC) constrictor responses in vitro and in vivo and neurogenic plasma extravasation in vivo in guinea-pig airways. Non-cholinergic contractions of guinea pig isolated bronchi, evoked by electrical field stimulation, were concentration-dependently inhibited by BW443C81 and morphine (10 nmol/1-100 mumol/l). In anaesthetised, artificially ventilated guinea pigs, frequency-related NC bronchoconstrictor responses evoked by antidromic electrical stimulation of the vagus nerves were reduced by BW443C81 (100 micrograms/kg/min i.v. infusion) and morphine (1 mg/kg i.v.). Neurogenic plasma extravasation produced by bilateral electrical vagal nerve stimulation in spontaneously breathing, anaesthetised guinea pigs was also inhibited by BW443C81 (1 mg/kg i.v.). The inhibitory effects of BW443C81 were reversed/prevented by naloxone. BW443C81 inhibits NC bronchoconstrictor responses and neurogenic plasma extravasation in guinea pig airways, consistent with its previously described mu-opioid receptor-mediated inhibitory action on airway sensory nerve function.
C E Shankley; C W Anderson; J J Adcock
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Agents and actions     Volume:  36     ISSN:  0065-4299     ISO Abbreviation:  Agents Actions     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-11-20     Completed Date:  1992-11-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0213341     Medline TA:  Agents Actions     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  22-8     Citation Subset:  IM    
Department of Pharmacology, Wellcome Research Laboratories, Beckenham, Kent, UK.
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MeSH Terms
Antitussive Agents / pharmacology*
Bronchi / drug effects
Bronchoconstrictor Agents / pharmacology*
Guinea Pigs
Morphine / pharmacology
Muscle Contraction / drug effects
Naloxone / pharmacology
Neurons, Afferent / drug effects,  metabolism*
Oligopeptides / pharmacology*
Respiration, Artificial
Reg. No./Substance:
0/Antitussive Agents; 0/Bronchoconstrictor Agents; 0/Oligopeptides; 465-65-6/Naloxone; 57-27-2/Morphine; 88331-14-0/BW 443C

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