Document Detail


Effect of BAY y 5959 on myocardial function and metabolism in normal and failing hearts.
MedLine Citation:
PMID:  9612364     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BAY y 5959 is a dihydropyridine derivative with positive inotropic actions mediated by a direct increase in intracellular calcium. We characterized the direct myocardial actions of this new agent in hearts isolated from seven normal dogs and from five dogs with repeated coronary microembolization-induced heart failure. Inotropic actions of BAY y 5959 were accompanied by little effect on duration of contraction and by prolongation of the monophasic action potential (MAP); in contrast, isoproterenol decreased contraction and MAP durations. Whereas inotropic responsiveness to isoproterenol was blunted in embolized hearts, these actions of BAY y 5959 were relatively preserved in the heart failure state. Isoproterenol increased heart rate, whereas BAY y 5959 had little effect. Changes in coronary vascular resistance also decreased similarly for isoproterenol and BAY y 5959. Finally, for comparable inotropy, increases in myocardial oxygen consumption were similar for isoproterenol and for BAY y 5959. In summary, preserved inotropic responsiveness and lack of positive chronotropic actions are two clinically favorable features of this type of inotropic agents compared with a typical beta-adrenergic agonist.
Authors:
K Todaka; J Wang; G H Yi; A Gu; S M Zhu; H Zhang; D Burkhoff
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of physiology     Volume:  274     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-06-24     Completed Date:  1998-06-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H1560-8     Citation Subset:  IM    
Affiliation:
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiotonic Agents / pharmacology*
Dihydropyridines / pharmacology*
Dogs
Heart / drug effects*,  physiology*
Heart Failure / metabolism*,  physiopathology*
Heart Rate / drug effects
Hemodynamics / drug effects
Myocardial Contraction / drug effects
Myocardium / metabolism*
Chemical
Reg. No./Substance:
0/BAY y 5959; 0/Cardiotonic Agents; 0/Dihydropyridines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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