Document Detail

Effect of Azadirachta indica leaves on rat spermatozoa.
MedLine Citation:
PMID:  10865894     Owner:  NLM     Status:  MEDLINE    
Histochemical studies and SEM observations on the morphological changes in the head of the spermatozoa in general, and the acrosome in particular, in A. indica treated rats are reported. In the treated rats change in the shape and size of the sperm head, with a dorso-ventral constriction of the middle region of the sperm head i.e., between the anterior and posterior regions was observed. It was rather difficult to differentiate the outer acrosomal and outer plasma membranes. A decrease in the perforatorium or sub-acrosomal material, post nuclear cap and the nuclear material near the basal plate at the base of the sperm head were also observed. The results suggest that the effects are probably due to androgen deficiency and a general disturbance in carbohydrates or polysaccharides located in the sperm head, caused by the antiandrogenic property of the leaves of A. indica.
R H Aladakatti; R N Ahamed
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of experimental biology     Volume:  37     ISSN:  0019-5189     ISO Abbreviation:  Indian J. Exp. Biol.     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-07-19     Completed Date:  2000-07-19     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0233411     Medline TA:  Indian J Exp Biol     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  1251-4     Citation Subset:  IM    
Department of Studies & Research in Zoology, Karnatak University, Dharwad, India.
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MeSH Terms
Acrosome / drug effects,  pathology
Androgen Antagonists / toxicity
Microscopy, Electron, Scanning
Plant Extracts / toxicity
Plant Leaves
Plants, Toxic*
Rats, Wistar
Spermatozoa / drug effects*,  pathology
Reg. No./Substance:
0/Androgen Antagonists; 0/Plant Extracts

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