Document Detail

Effect of atypical antipsychotics on fetal growth: is the placenta involved?
MedLine Citation:
PMID:  22848828     Owner:  NLM     Status:  MEDLINE    
There is currently considerable uncertainty regarding prescribing practices for pregnant women with severe and persistent psychiatric disorders. The physician and the mother have to balance the risks of untreated psychiatric illness against the potential fetal toxicity associated with pharmacological exposure. This is especially true for women taking atypical antipsychotics. Although these drugs have limited evidence for teratological risk, there are reports of altered fetal growth, both increased and decreased, with maternal atypical antipsychotic use. These effects may be mediated through changes in the maternal metabolism which in turn impacts placental function. However, the presence of receptors targeted by atypical antipsychotics in cell lineages present in the placenta suggests that these drugs can also have direct effects on placental function and development. The signaling pathways involved in linking the effects of atypical antipsychotics to placental dysfunction, ultimately resulting in altered fetal growth, remain elusive. This paper focuses on some possible pathways which may link atypical antipsychotics to placental dysfunction.
Sandeep Raha; Valerie H Taylor; Alison C Holloway
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-07-11
Journal Detail:
Title:  Journal of pregnancy     Volume:  2012     ISSN:  2090-2735     ISO Abbreviation:  J Pregnancy     Publication Date:  2012  
Date Detail:
Created Date:  2012-07-31     Completed Date:  2013-06-03     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  101553823     Medline TA:  J Pregnancy     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  315203     Citation Subset:  IM    
Department of Pediatrics, McMaster University, 1200 Main Street West, Room 3N11, Hamilton, ON, Canada L8N 3Z5.
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MeSH Terms
Antipsychotic Agents / adverse effects*,  therapeutic use
Fetal Development / drug effects*
Mental Disorders / drug therapy*
Oxidative Stress / drug effects
Placenta / drug effects*,  metabolism,  physiopathology
Pregnancy Complications / drug therapy*
Reg. No./Substance:
0/Antipsychotic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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