| Effect of atorvastatin on cardiac remodelling and mortality in rats following hyperglycemia and myocardial infarction. | |
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MedLine Citation:
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PMID: 19395095 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: The presence of diabetes mellitus (DM) in patients with myocardial infarction (MI) increases mortality, due in part to the presence of known cardiovascular risk factors. However little is known about the impact of DM on cardiac remodelling and on clinical outcomes. We aimed to investigate whether hyperglycaemia may adversely and additionally affect LV remodelling post-MI, and whether the addition of a statin, known to reduce mortality both post MI and in humans with DM, has an effect on these outcomes. Methods: Eight week old Sprague-Dawley rats were allocated to 5 groups--control (non-DM)/sham, control-MI, DM-sham, DM-MI and DM-MI with statin gavage (DM-MI/ATV). Echocardiogram and invasive pressure volume analysis were performed prior to sacrifice for estimation of cardiac function. Tissue was analysed for total cardiac collagen, collagen I and III. Results: Hyperglycaemia in the remodelling period significantly increased mortality (70% survival in the C-MI group vs 27% in the DM-MI group), worsened cardiac function and increased fibrosis. All of these variables were attenuated by the addition of a statin. Conclusion: Hyperglycaemia increased mortality in MI and exacerbated LV remodeling, and this was attenuated with statin use. This study confirms the importance of early and intensive treatment of hyperglycaemia in patients with MI and suggests that in humans with both DM and MI the addition of a statin may be beneficial. |
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Authors:
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Jennifer H Martin; Kim A Connelly; Andrew Boyle; Andrew Kompa; Yuan Zhang; Darren Kelly; Richard E Gilbert; Henry Krum |
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Publication Detail:
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Type: Journal Article Date: 2009-04-22 |
Journal Detail:
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Title: International journal of cardiology Volume: 143 ISSN: 1874-1754 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-13 Completed Date: 2010-12-30 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 353-60 Citation Subset: IM |
Copyright Information:
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Copyright © 2009 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Diamantina Institute, The University of Queensland, Royal Brisbane and Women's Hospital, Queensland, Australia. Jennifer_H_Martin@health.qld.gov.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Weight / drug effects Cardiac Volume / drug effects Collagen Type I / metabolism Collagen Type III / metabolism Diabetes Mellitus, Experimental / mortality Disease Models, Animal Female Fibrosis Heptanoic Acids / pharmacology* Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology Hyperglycemia / mortality* Myocardial Infarction / drug therapy*, mortality*, pathology Myocardium / metabolism, pathology Pyrroles / pharmacology* Rats Rats, Sprague-Dawley Ventricular Remodeling / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Collagen Type I; 0/Collagen Type III; 0/Heptanoic Acids; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Pyrroles; A0JWA85V8F/atorvastatin |
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