Document Detail


Effect of atorvastatin on cardiac remodelling and mortality in rats following hyperglycemia and myocardial infarction.
MedLine Citation:
PMID:  19395095     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: The presence of diabetes mellitus (DM) in patients with myocardial infarction (MI) increases mortality, due in part to the presence of known cardiovascular risk factors. However little is known about the impact of DM on cardiac remodelling and on clinical outcomes. We aimed to investigate whether hyperglycaemia may adversely and additionally affect LV remodelling post-MI, and whether the addition of a statin, known to reduce mortality both post MI and in humans with DM, has an effect on these outcomes.
METHODS: Eight week old Sprague-Dawley rats were allocated to 5 groups--control (non-DM)/sham, control-MI, DM-sham, DM-MI and DM-MI with statin gavage (DM-MI/ATV). Echocardiogram and invasive pressure volume analysis were performed prior to sacrifice for estimation of cardiac function. Tissue was analysed for total cardiac collagen, collagen I and III.
RESULTS: Hyperglycaemia in the remodelling period significantly increased mortality (70% survival in the C-MI group vs 27% in the DM-MI group), worsened cardiac function and increased fibrosis. All of these variables were attenuated by the addition of a statin.
CONCLUSION: Hyperglycaemia increased mortality in MI and exacerbated LV remodeling, and this was attenuated with statin use. This study confirms the importance of early and intensive treatment of hyperglycaemia in patients with MI and suggests that in humans with both DM and MI the addition of a statin may be beneficial.
Authors:
Jennifer H Martin; Kim A Connelly; Andrew Boyle; Andrew Kompa; Yuan Zhang; Darren Kelly; Richard E Gilbert; Henry Krum
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Publication Detail:
Type:  Journal Article     Date:  2009-04-22
Journal Detail:
Title:  International journal of cardiology     Volume:  143     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-13     Completed Date:  2010-12-30     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  353-60     Citation Subset:  IM    
Copyright Information:
Copyright © 2009 Elsevier Ireland Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight / drug effects
Cardiac Volume / drug effects
Collagen Type I / metabolism
Collagen Type III / metabolism
Diabetes Mellitus, Experimental / mortality
Disease Models, Animal
Female
Fibrosis
Heptanoic Acids / pharmacology*
Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology
Hyperglycemia / mortality*
Myocardial Infarction / drug therapy*,  mortality*,  pathology
Myocardium / metabolism,  pathology
Pyrroles / pharmacology*
Rats
Rats, Sprague-Dawley
Ventricular Remodeling / drug effects*
Chemical
Reg. No./Substance:
0/Collagen Type I; 0/Collagen Type III; 0/Heptanoic Acids; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Pyrroles; A0JWA85V8F/atorvastatin

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