Document Detail


Effect of Asparagus-P on cell metabolism of cultured kidney and inflammation-mediating cells.
MedLine Citation:
PMID:  18972586     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Asparagus-P is a traditional herbal medicinal product consisting of a combination of dried and pulverized asparagus roots and parsley leaves in equal parts. It is commonly used to support aquaretic kidney function, i.e. the increased excretion of water from the kidneys without affecting electrolyte balance. The mechanisms of this aquaretic effectiveness are widely unknown and are controversial. By using two different kidney cell lines (distal tubule-derived Madin-Darby bovine kidney (MDBK) cells and proximal tubule-derived opossum kidney (OK) cells) the study investigated whether a stimulation of basal kidney cell metabolism might be responsible for the increased excretion of water from the kidneys. The results demonstrate that Asparagus-P was able to stimulate the metabolism of both kidney cell lines in a dose-dependent manner with a maximum stimulation at the recommended daily dosage after distribution in the whole body fluid. Metabolic stimulation was much more pronounced for OK than for MDBK cells. Whether a stimulation of cell metabolism correlates with an increased water excretion is currently unknown, but in vitro data might deliver the first evidence for a better understanding of the mechanism of action. Moreover, Asparagus-P inhibited the metabolism of inflammation-mediating cells (differentiated human promyelocytes). This increases the information on the antiinflammatory efficacy of Asparagus-P as already shown by its potential to inactivate reactive oxygen radicals.
Authors:
Peter C Dartsch
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  22     ISSN:  1099-1573     ISO Abbreviation:  Phytother Res     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-04     Completed Date:  2008-12-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1477-81     Citation Subset:  IM    
Affiliation:
Dartsch Scientific GmbH, Institut für zellbiologische Testsysteme, D-86956 Schongau/Oberbayern, Germany. pc.dartsch@dartsch-scientific.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Inflammatory Agents / pharmacology
Asparagus Plant / chemistry*
Cattle
Cell Line
Granulocyte Precursor Cells / drug effects,  metabolism*
Humans
Kidney Tubules, Distal / drug effects,  metabolism*
Kidney Tubules, Proximal / drug effects,  metabolism*
Opossums
Petroselinum / chemistry*
Phytotherapy
Plant Leaves / chemistry
Plant Roots / chemistry
Time Factors
Water / metabolism*
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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