Document Detail

Effect of Ascaris trypsin inhibitor on fetal development of mice.
MedLine Citation:
PMID:  16838622     Owner:  NLM     Status:  MEDLINE    
In this study, maternal toxicity and developmental effects of exposure to Ascaris trypsin inhibitor were evaluated in mice. Pregnant BALB/c females were injected intraperitoneally by Ascaris inhibitor /AIT/ at 200, 300, and 400 mg/kg body weight/day, on days 12 to 15 of gestation (stage of fetal development). At day 19 of pregnancy, uterine contents were inspected for implantation sites, early resorptions (moles), living fetuses and dead fetuses. The living fetuses were weighed and examined for external, internal and skeletal abnormalities. The results showed that AIT induced maternal toxicity, evidenced by maternal deaths, abortions, bleeding from uterus and reduced body weight gain as compared to control (p < 0.01). There were no differences between the control group and the rest of all groups investigated for total implantation sites and early resorptions. Fetotoxicity was observed as shown by the decrease in the number of living fetuses and mean fetal weight, a high rate of intrauterine fetal deaths, delayed skeletal ossification, occurrence of pathological changes of fetal organs and tissues. Only one type of congenital malformations (hydronephrosis) was noted in fetuses after injection of higher doses of AIT.
Joanna Błaszkowska
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Wiadomości parazytologiczne     Volume:  51     ISSN:  0043-5163     ISO Abbreviation:  Wiad Parazytol     Publication Date:  2005  
Date Detail:
Created Date:  2006-07-14     Completed Date:  2006-09-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0420554     Medline TA:  Wiad Parazytol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  133-8     Citation Subset:  IM    
Department of Biology and Medical Parasitology, Chair of Biology and Medical Genetics, Medical University, P1. Hallera 1, 90-647 Lódź.
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MeSH Terms
Abnormalities, Drug-Induced*
Birth Weight / drug effects
Fetal Death / chemically induced
Fetal Development / drug effects*
Fetal Resorption / chemically induced
Fetal Weight / drug effects
Helminth Proteins
Insect Proteins / toxicity*
Mice, Inbred BALB C
Organ Size / drug effects
Pregnancy Outcome
Pregnancy, Animal / drug effects*
Teratogens / toxicity
Reg. No./Substance:
0/Helminth Proteins; 0/Insect Proteins; 0/Teratogens; 0/trypsin inhibitor, Ascaris

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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