| Effect of Arctium lappa L. in the dextran sulfate sodium colitis mouse model. | |
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MedLine Citation:
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PMID: 20806438 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To analyze the possible protective role of Arctium lappa L. (AL) in a murine model of ulcerative colitis (UC). METHODS: BALB/c mice were administered 100 mg/kg AL powder orally each day. After 7 d, colitis was induced by administration of dextran sulfate sodium (DSS) (5% W/V) in drinking water for a further 8 consecutive days. Diarrhea and bloody stools as well as colonic histology were observed. The level of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in colonic sections were detected by immunohistochemistry. RESULTS: There were significant differences in mean body weight values and disease activity indices between controls and AL-treated animals. Moreover, the histological findings showed that AL treatment can prevent mucosal edema, submucosal erosions, ulceration, inflammatory cell infiltration and colon damage. In addition, immunohistochemistry analysis showed that the levels of the inflammatory cytokines, IL-6 and TNF-alpha were also decreased in AL-treated groups. CONCLUSION: We suggest that AL can prevent intestinal damage and decrease inflammatory cytokines in mice with DSS-induced colitis. Thus, AL could prove to be a useful food for UC. |
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Authors:
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Tzou-Chi Huang; Shinn-Shyong Tsai; Li-Fang Liu; Yu Lin Liu; Hung-Jen Liu; Kuo Pin Chuang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 16 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-31 Completed Date: 2010-12-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 4193-9 Citation Subset: IM |
Affiliation:
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Graduate Institute of Animal Vaccine Technology, National Pingtung University of Science and Technology, 912 Pingtung, Taiwan, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Arctium* Colitis, Ulcerative / chemically induced*, drug therapy*, metabolism Colon / metabolism Dextran Sulfate / adverse effects* Disease Models, Animal Edema / prevention & control Interleukin-6 / metabolism Mice Mice, Inbred BALB C Phytotherapy* Plant Preparations / administration & dosage, pharmacology, therapeutic use* Tumor Necrosis Factor-alpha / metabolism Ulcer / prevention & control Weight Loss / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-6; 0/Plant Preparations; 0/Tumor Necrosis Factor-alpha; 9042-14-2/Dextran Sulfate |
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