| The effect of antihypertensive agents on insulin sensitivity, lipids and haemostasis. | |
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MedLine Citation:
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PMID: 20626344 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Antihypertensive agents exert different effects on insulin sensitivity, lipids and haemostasis. However, most studies assessing these effects were small and short-term yielding conflicting results. Moreover, it has not been established whether the impact of antihypertensive drugs on insulin sensitivity, lipids, thrombosis and fibrinolysis adds to or attenuates vascular risk reduction. On the other hand, new onset type 2 diabetes mellitus (T2DM) appears to be more frequent in patients treated with β-blockers and diuretics, whereas angiotensin converting enzyme inhibitors and angiotensin receptor blockers might reduce the risk for T2DM and calcium channel blockers have a neutral effect. Therefore, the risk of developing T2DM should be considered when selecting an antihypertensive agent. This review discusses the differential effects of antihypertensive drugs on insulin sensitivity, lipids and haemostasis and considers their association with vascular risk. |
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Authors:
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Asterios Karagiannis; Konstantinos Tziomalos; Panagiotis Anagnostis; Thomas D Gossios; Matilda Florentin; Vasilios G Athyros; Dimitri P Mikhailidis |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Current vascular pharmacology Volume: 8 ISSN: 1875-6212 ISO Abbreviation: Curr Vasc Pharmacol Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-09-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101157208 Medline TA: Curr Vasc Pharmacol Country: United Arab Emirates |
Other Details:
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Languages: eng Pagination: 792-803 Citation Subset: IM |
Affiliation:
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Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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