Document Detail

Effect of Antiepilepsy Drug Therapy on Ventricular Function in Children With Epilepsy: A Tissue Doppler Imaging Study.
MedLine Citation:
PMID:  23942784     Owner:  NLM     Status:  Publisher    
Impaired cardiac myocardial function may contribute to the risk for sudden unexpected death of a patient with epilepsy. This study aimed to investigate the effect of antiepilepsy drugs (AEDs) on cardiac function in pediatric epileptic patients using standard and tissue Doppler imaging (TDI) echocardiography. This hospital-based, prospective cross-sectional study investigated 52 epileptic children (mean age 9.3 ± 3.1 years) treated with AEDs (duration 2.4-10.0 years) and 36 healthy children (mean age 9.5 ± 4.0 years). In the epilepsy group, standard echocardiography showed increased left ventricular (LV) end-diastolic and end-systolic diameters, an increased LV mass index, and preserved ejection fraction. The patients also exhibited increased mitral peak A-wave velocity and mitral E-wave deceleration time as well as a decreased mitral E/A ratio. The E/Em ratio was significantly higher in the epilepsy group (5.6 ± 1.2) than in the control group (5.2 ± 1.1) (p = 0.016). In the epilepsy group, TDI showed an increased isovolumetric relaxation time and myocardial performance index (MPI). It also exhibited decreased early diastolic velocity (Em) and a decreased mitral annular displacement index in these patients. There were positive correlations between the LV lateral wall MPI (r = 0.231), septal MPI (r = 0.223), and LV mass index (p < 0.05) but no correlation with the duration of AED treatment. The authors detected subclinical ventricular dysfunction associated with AEDs at a preclinical stage. They suggest that TDI can be useful for determining the short- and long-term cardiac effects of AEDs.
Ayse Esin Kibar; Olcay Unver; Mehmet Burhan Oflaz; Ahmet Sami Güven; Sevket Balli; Ibrahim Ece; Sevcan Erdem; Fusun Dilara Içağasıoğlu
Related Documents :
6846154 - Prognostic and predictive value of exertional hypotension in suspected coronary heart d...
8581514 - Evidence against heterozygous coagulation factor v 1691 g-->a mutation with resistance ...
19105094 - Novel atherogenesis markers for identification of patients with a multivessel coronary ...
18497554 - The effect of postural changes (leg lifting) on tissue doppler parameters in coronary a...
24753824 - Main complications of mild induced hypothermia after cardiac arrest: a review article.
22661744 - Self-reported cocaine use, emergency physician testing and outcomes in suspected acute ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-8-13
Journal Detail:
Title:  Pediatric cardiology     Volume:  -     ISSN:  1432-1971     ISO Abbreviation:  Pediatr Cardiol     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-8-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003849     Medline TA:  Pediatr Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Pediatric Cardiology, Mersin Women's and Children's Hospital, Güneykent, Mersin, Turkey,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Paracetamol Therapy for Patent Ductus Arteriosus in Premature ?nfants: A Chance Before Surgical Liga...
Next Document:  Increased serum levels of S100A8/A9 and S100A12 are associated with cardiovascular disease in patien...