Document Detail


Effect of Antenatal Tocolysis on Neonatal Outcomes.
MedLine Citation:
PMID:  22873356     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Objective: Detail adverse neonatal effects in pregnancies treated with indomethacin (I), magnesium sulfate (M), or nifedipine (N). Methods: Women in acute preterm labor with cervical dilatation 1-6cm were randomized to receive one of three first line tocolytic drugs. Results: There were 317 neonates (I=103, M=95, N=119) whose mothers were treated with tocolytic therapy. There was no difference in gestational age at randomization (average 28.6 weeks' gestation) or at delivery (31.6 weeks' gestation, P=0.551), birth weight (P=0.871), or ventilator days (P=0.089) between the three groups. Neonatal morbidity was not different between the three groups; RDS (P=0.086), PDA (P=0.592), sepsis (P=0.590), NEC (P=0.770), IVH (P=0.669), and PVL (P=0.124). Conclusions: There were no statistically significant differences between the three tocolytics as far as composite neonatal morbidity or mortality was concerned.
Authors:
Chad K Klauser; Christian M Briery; Sharon D Keiser; Rick W Martin; Mary A Kosek; John C Morrison
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-9
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
From the Departments of Obstetrics and Gynecology; The Mount Sinai Medical Center, New York City, New York.
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