Document Detail

The effect of antenatal steroids on fetal lung maturation between the 34th and 36th week of pregnancy.
MedLine Citation:
PMID:  20234136     Owner:  NLM     Status:  MEDLINE    
AIM: To evaluate the effect of antenatal treatment with a single dose of betamethasone between the 34th and the 36th week of pregnancy on the maturation of fetal lung.
METHODS: To study 100 pregnant women in their 34th-36th week of pregnancy who were diagnosed as susceptible to have preterm delivery. Fifty patients did not receive betamethasone (group 1). The other 50 patients were administered 12 mg betamethasone in a single dose (group 2). Patients who delivered at least 24 h after the administration of betamethasone were included in this study. After delivery, the Apgar score and the development of respiratory distress syndrome (RDS) in the neonates were compared.
RESULTS: Group 2 babies had better Apgar scores when compared to group 1, and the difference was statistically significant. Sixteen (32%) neonates of group 1 and 7 (14%) neonates of group 2 required resuscitation, and the difference was statistically significant (p = 0.032; OR = 0.34, 95% CI 0.12-0.93). RDS was detected in 8 newborns of group 1 and 2 of group 2. The difference was statistically significant (p = 0.046; OR = 0.21, 95% CI 0.04-1.08).
CONCLUSION: The administration of a single dose of betamethasone to pregnant women in their 34th-36th week of pregnancy who are likely to have preterm delivery reduces RDS development. There is a need for larger studies to confirm these results.
Osman Balci; Suna Ozdemir; Alaa S Mahmoud; Ali Acar; Mehmet C Colakoglu
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2010-03-17
Journal Detail:
Title:  Gynecologic and obstetric investigation     Volume:  70     ISSN:  1423-002X     ISO Abbreviation:  Gynecol. Obstet. Invest.     Publication Date:  2010  
Date Detail:
Created Date:  2010-08-24     Completed Date:  2010-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7900587     Medline TA:  Gynecol Obstet Invest     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  95-9     Citation Subset:  IM    
Copyright Information:
Copyright 2010 S. Karger AG, Basel.
Department of Obstetrics and Gynecology, Meram Medicine Faculty, Selcuk University, Konya, Turkey.
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MeSH Terms
Apgar Score
Betamethasone / administration & dosage*
Follow-Up Studies
Glucocorticoids / administration & dosage*
Infant, Newborn
Lung / drug effects,  embryology*
Pregnancy Complications / prevention & control*
Pregnancy Trimester, Third
Prospective Studies
Respiratory Distress Syndrome, Newborn / prevention & control*
Young Adult
Reg. No./Substance:
0/Glucocorticoids; 378-44-9/Betamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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