| Effect of Antenatal Corticosteroid Treatment on Lung Function in Full-Term Newborn Infants. | |
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MedLine Citation:
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PMID: 21196776 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: Antenatal treatment of pregnant women with corticosteroids in order to stimulate surfactant production has been shown to be effective. However, lung structure is also affected by the treatment. Objective: We tested the hypothesis that changes within lung acini, induced by maternal corticosteroid treatment, persist during lung development. Methods: Twenty-two healthy infants, whose mothers were treated with up to three doses of betamethasone at 25-33 weeks of pregnancy because of preterm labour, but where labour terminated and the infants were born at term, were studied at term and compared to a group of 50 healthy newborn infants without prenatal treatment with corticosteroids. Gas-mixing efficiency was measured in terms of moment ratio with a nitrogen washout method together with functional residual capacity. Mechanical parameters were assessed with the single occlusion technique. Results: There were no signs of disturbed gas mixing or changed lung volume or mechanics in the treated group. Conclusion: The result contributes to an emerging body of evidence that antenatal treatment with corticosteroids does not permanently affect lung structure or function. |
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Authors:
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Ola Hjalmarson; Kenneth L Sandberg |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-12-22 |
Journal Detail:
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Title: Neonatology Volume: 100 ISSN: 1661-7819 ISO Abbreviation: - Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2011-1-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101286577 Medline TA: Neonatology Country: - |
Other Details:
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Languages: ENG Pagination: 32-36 Citation Subset: - |
Copyright Information:
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Copyright © 2010 S. Karger AG, Basel. |
Affiliation:
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Department of Paediatrics, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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