Document Detail

The Effect of an Amphiphilic Self-assembled Lipid Lamellar Phase on the Relief of Dry Skin.
MedLine Citation:
PMID:  22882126     Owner:  NLM     Status:  Publisher    
Humectant and occlusive technologies have been used traditionally for the treatment of dry skin. Originally, non-lamellar forming ingredients were used such as Petrolatum but recent research has shown the advantage of using lamellar-forming ingredients such as ceramides, pseudoceramides and phospholipids in the relief of dry skin. Nevertheless, the importance of using lipid phase transition inducers such as long chain fatty acids have not been studied clinically. We were interested in evaluating a novel complex of lipophilic ingredients: Cetyl Alcohol, Isostearyl Isostearate, Potassium Cetyl Phosphate, Cetyl Behenate and Behenic Acid. The combination of all ingredients was shown to be more effective than any single component in water vapour transmission rate studies. This was thought to be due to the formation of a unique structural organization of the lipids upon dry down from an O/W emulsion as was examined by X-ray diffraction and optical microscopy. When evaluated clinically in a randomized double blind and vehicle-controlled moisturisation efficacy trial, this novel blend of ingredients was shown to not only improve the visible signs of skin dryness to a significantly greater extent than a comparable Mineral Oil containing vehicle but also then maintain a better skin condition during the regression no treatment phase of the study. This combination of ingredients offers a new technology option for the treatment of dry skin. © 2012 Society of Cosmetic Scientists and the Société Française de Cosmétologie.
Graham Pennick; Bhaven Chavan; Beverley Summers; Anthony V Rawlings
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-8
Journal Detail:
Title:  International journal of cosmetic science     Volume:  -     ISSN:  1468-2494     ISO Abbreviation:  Int J Cosmet Sci     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8007161     Medline TA:  Int J Cosmet Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Society of Cosmetic Scientists and the Société Française de Cosmétologie.
Croda Consumer Care Europe, Goole, East Yorkshire, UK.
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