| Effect of amlodipine + candesartan on cardiovascular events in hypertensive patients with coronary artery disease (from The Heart Institute of Japan Candesartan Randomized Trial for Evaluation in Coronary Artery Disease [HIJ-CREATE] Study). | |
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MedLine Citation:
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PMID: 20816122 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Combination therapy with calcium channel blockers and angiotensin II receptor blockers is recommended as one of the effective therapies for hypertension. However, it remains unclear whether this combination reduces major adverse cardiovascular events (MACEs) in patients with hypertension with coronary artery disease (CAD). The purpose of the present study was to examine the effects of amlodipine plus candesartan on MACEs in patients with hypertension with CAD. The study population was drawn from The Heart Institute of Japan Candesartan Randomized Trial for Evaluation in Coronary Artery Disease (HIJ-CREATE), which was a multicenter, prospective, randomized controlled trial including 2,049 patients with hypertension with angiographically documented CAD. Subgroup analysis was performed in patients treated with amlodipine at baseline (n = 388). The median follow-up period was 4.3 years. Treatment using amlodipine plus candesartan reduced the risk for MACEs by 39% (p = 0.015) compared to that using amlodipine without angiotensin II receptor blockers. Among the individual events constituting MACEs, the incidence of unstable angina pectoris requiring hospitalization was significantly lower, by 52% (p = 0.007). In conclusion, amlodipine plus candesartan demonstrated a more favorable effect on reducing cardiovascular events in patients with hypertension with CAD compared to amlodipine-based therapy without candesartan. |
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Authors:
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Junichi Yamaguchi; Nobuhisa Hagiwara; Hiroshi Ogawa; Ryo Koyanagi; Hiroshi Kasanuki; Atsushi Takagi; Fumiaki Mori; Michitaka Nagashima; Masahiro Yagi; |
Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2010-08-02 |
Journal Detail:
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Title: The American journal of cardiology Volume: 106 ISSN: 1879-1913 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-06 Completed Date: 2010-09-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 819-24 Citation Subset: AIM; IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Cardiology, The Heart Institute of Japan, Tokyo Women's Medical University, Tokyo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Amlodipine / therapeutic use* Angina, Unstable / etiology, prevention & control Angiotensin II Type 1 Receptor Blockers / therapeutic use* Antihypertensive Agents / therapeutic use* Benzimidazoles / therapeutic use* Coronary Artery Disease / complications, drug therapy* Drug Therapy, Combination Female Follow-Up Studies Humans Hypertension / complications, drug therapy* Japan Male Middle Aged Risk Factors Tetrazoles / therapeutic use* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin II Type 1 Receptor Blockers; 0/Antihypertensive Agents; 0/Benzimidazoles; 0/Tetrazoles; 139481-59-7/candesartan; 88150-42-9/Amlodipine |
| Investigator | |
Investigator/Affiliation:
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Hiroshi Kasanuki / ; Nobuhisa Hagiwara / ; Saichi Hosoda / ; Tetsuya Sumiyoshi / ; Takashi Honda / ; Kazuo Haze / ; Hiroshi Ogawa / ; Masahiro Yagi / ; Junichi Yamaguchi / ; Ryo Koyanagi / ; Keiji Ueda / ; Hiroshi Matsuo / ; Hideki Origasa / ; Hirokazu Hayakawa / ; Tadanori Aizawa / ; Kazuzo Kato / ; Katsunori Shimada / ; Atsushi Takagi / ; Ryuta Asano / ; Akira Ito / ; Koichi Nakao / ; Tatsuro Uchida / ; Toshiaki Oka / ; Kamon Imai / ; Yasuhiro Endoh / ; Kazunori Iwade / ; Naohide Tanaka / ; Tatsuro Ueda / ; Hiroyuki Tanaka / ; Masao Kawaguchi / ; Satoshi Ohnishi / ; Yasuhiro Kawagoe / ; Naoya Fujita / ; Takao Yamauchi / |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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