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Effect of Amiodarone on Dispersion of Ventricular Repolarization in a Canine Congestive Heart Failure Model.
MedLine Citation:
PMID:  22229329     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
1. The effects of amiodarone on ventricular electrophysiological parameters, especially the dispersion of ventricular repolarization, were investigated in a canine model of congestive heart failure (CHF). 2. Dogs were randomized to either a control, amiodarone, CHF, or CHF + amiodarone group. Dogs in the CHF and CHF + amiodarone groups underwent 4-5 weeks of rapid ventricular pacing; dogs in the control and amiodarone groups underwent only a sham operation. Amiodarone 20mg/kg/day was administered orally beginning on day 1 post-operatively in the treatment groups, and ventricular electrophysiological variables were evaluated 4-5 weeks after rapid pacing or sham operation. 3. In CHF dogs, the transmural dispersion ventricular repolarization time (TDVRT) increased significantly. Amiodarone significantly decreased TDVRT in CHF dogs. Ventricular fibrillation threshold (VFT) decreased in the CHF group. Amiodarone increased VFT in CHF dogs. 4. TDVRT increased in CHF dogs. Amiodarone decreased TDVRT and increased VFT in these dogs. Our results suggest a beneficial effect of amiodarone on malignant arrhythmias and may provide guidance for its use in CHF patients. © 2012 The Authors Clinical and Experimental Pharmacology and Physiology© 2012 Blackwell Publishing Asia Pty Ltd.
Authors:
Shu-Xian Zhou; Chang Fang; Shao-Xin Zheng; Yu-Ling Zhang; Juan Lei; Jing-Feng Wang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-9
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  -     ISSN:  1440-1681     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors Clinical and Experimental Pharmacology and Physiology © 2012 Blackwell Publishing Asia Pty Ltd.
Affiliation:
Division of Cardiology, Department of Internal Medicine, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, China.
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