Document Detail


Effect of allergen inhalation on airway oxidant stress, using exhaled breath condensate 8-isoprostane, in mild asthma.
MedLine Citation:
PMID:  23461590     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Exhaled breath condensate (EBC) 8-isoprostane concentrations are increased in asthma, but it is not known if they acutely change following bronchoprovocation. The objective of this study was to evaluate EBC 8-isoprostane concentrations following allergen-induced bronchoprovocation in asthma.
METHODS: This comparison study included eight mild atopic asthmatics and six controls. Asthmatics were challenged with inhaled specific allergen, methacholine, and irrelevant allergen in random order. Controls were challenged with irrelevant allergen. EBCs collected at 0, 3, 6, 9, and 23 hours by the R-tube method were measured for 8-isoprostanes by ELISA technique. Repeated measures ANOVA technique was used for analysis.
RESULTS: EBC 8-isoprostane concentrations did not change following any inhalational challenge, as compared to baseline, in either asthmatics or controls.
CONCLUSIONS: EBC 8-isoprostane concentrations do not acutely change following bronchoprovocation in subjects with mild asthma.
Authors:
Akshay Sood; Clifford Qualls; JeanClare Seagrave; Jacob McDonald; Rugia Shohreh; Annalisa Chiavaroli; Mark Schuyler
Publication Detail:
Type:  Journal Article     Date:  2013-04-10
Journal Detail:
Title:  The Journal of asthma : official journal of the Association for the Care of Asthma     Volume:  50     ISSN:  1532-4303     ISO Abbreviation:  J Asthma     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-21     Completed Date:  2013-07-19     Revised Date:  2013-12-11    
Medline Journal Info:
Nlm Unique ID:  8106454     Medline TA:  J Asthma     Country:  England    
Other Details:
Languages:  eng     Pagination:  449-56     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Adult
Allergens / immunology*
Asthma / metabolism*
Breath Tests*
Bronchi / metabolism*
Dinoprost / analogs & derivatives*,  analysis
Enzyme-Linked Immunosorbent Assay
Female
Humans
Middle Aged
Oxidative Stress*
Radioimmunoassay
Grant Support
ID/Acronym/Agency:
UL1 TR000041/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
0/Allergens; 27415-26-5/8-epi-prostaglandin F2alpha; B7IN85G1HY/Dinoprost

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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