| Effect of alginate on satiation, appetite, gastric function, and selected gut satiety hormones in overweight and obesity. | |
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MedLine Citation:
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PMID: 19960001 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lack of control of food intake, excess size, and frequency of meals are critical to the development of obesity. The stomach signals satiation postprandially and may play an important role in control of calorie intake. Sodium alginate (based on brown seaweed Laminaria digitata) is currently marketed as a weight loss supplement, but its effects on gastric motor functions and satiation are unknown. We evaluated effects of 10 days treatment with alginate or placebo on gastric functions, satiation, appetite, and gut hormones associated with satiety in overweight or obese adults. We conducted a randomized, 1:1, placebo-controlled, allocation-concealed study in 48 overweight or obese participants with excluded psychiatric comorbidity and binge eating disorder. All underwent measurements of gastric emptying (GE), fasting, and postprandial gastric volumes (GVs), postprandial satiation, calorie intake at a free choice meal and selected gut hormones after 1 week of alginate (three capsules vs. matching placebo per day, ingested 30 min before the main meal). Six capsules were ingested with water 30 min before the GE, GV, and satiation tests on days 8-10. There were no treatment group effects on GE or volumes, gut hormones (ghrelin, cholecystokinin (CCK), glucagon-like peptide-1 (GLP-1), peptide YY (PYY)), satiation, total and macronutrient calorie intake at a free choice meal. There was no difference detected in results between obese and overweight patients. Alginate treatment for a period of 10 days showed no effect on gastric motor functions, satiation, appetite, or gut hormones. These results question the use of short-term alginate treatment for weight loss. |
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Authors:
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Suwebatu T Odunsi; María I Vázquez-Roque; Michael Camilleri; Athanasios Papathanasopoulos; Matthew M Clark; Lynne Wodrich; Mary Lempke; Sanna McKinzie; Michael Ryks; Duane Burton; Alan R Zinsmeister |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural Date: 2009-12-03 |
Journal Detail:
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Title: Obesity (Silver Spring, Md.) Volume: 18 ISSN: 1930-739X ISO Abbreviation: Obesity (Silver Spring) Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-28 Completed Date: 2011-02-10 Revised Date: 2012-08-13 |
Medline Journal Info:
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Nlm Unique ID: 101264860 Medline TA: Obesity (Silver Spring) Country: United States |
Other Details:
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Languages: eng Pagination: 1579-84 Citation Subset: IM |
Affiliation:
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Division of Biomedical Statistics and Bioinformatics, Mayo Clinic College of Medicine, Rochester, Minnesota, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alginates / pharmacology*, therapeutic use Energy Intake / drug effects Female Gastric Emptying / drug effects Glucuronic Acid / pharmacology, therapeutic use Hexuronic Acids / pharmacology, therapeutic use Hormones / metabolism Humans Laminaria / chemistry* Male Obesity / drug therapy*, metabolism Overweight / drug therapy*, metabolism Plant Extracts / pharmacology*, therapeutic use Postprandial Period Satiation / drug effects Single-Blind Method |
| Grant Support | |
ID/Acronym/Agency:
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K24 DK002638-10/DK/NIDDK NIH HHS; K24 DK02638/DK/NIDDK NIH HHS; R01 DK067071/DK/NIDDK NIH HHS; R01 DK067071-05/DK/NIDDK NIH HHS; R01 DK67071/DK/NIDDK NIH HHS; RR0024150/RR/NCRR NIH HHS; UL1 RR024150-01/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Alginates; 0/Hexuronic Acids; 0/Hormones; 0/Plant Extracts; 576-37-4/Glucuronic Acid; 9005-32-7/alginic acid |
| Comments/Corrections | |
Comment In:
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Obesity (Silver Spring). 2010 Nov;18(11):2069; author reply 2070
[PMID:
20978479
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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