Document Detail

Effect of ageing on left ventricular compliance and distensibility in healthy sedentary humans.
MedLine Citation:
PMID:  22331419     Owner:  NLM     Status:  MEDLINE    
Healthy, but sedentary ageing leads to marked atrophy and stiffening of the heart, with substantially reduced cardiac compliance; but the time course of when this process occurs during normal ageing is unknown. Seventy healthy sedentary subjects (39 female; 21–77 years) were recruited from the Dallas Heart Study, a population-based, random community sample and enriched by a second random sample from employees of Texas Health Resources. Subjects were highly screened for co-morbidities and stratified into four groups according to age: G(21−34): 21–34 years, G(35−49): 35–49 years, G5(0−64): 50–64 years, G(≥65): ≥65 years. All subjects underwent invasive haemodynamic measurements with right heart catheterization to define Starling and left ventricular (LV) pressure–volume curves. LV end-diastolic volumes (EDV) were measured by echocardiography at baseline, −15 and −30 mmHg lower-body negative pressure, and 15 and 30 ml kg(−1) saline infusion with simultaneous measurements of pulmonary capillary wedge pressure. There were no differences in heart rate or blood pressures among the four groups at baseline. Baseline EDV index was smaller in G(≥65) than other groups. LV diastolic pressure–volume curves confirmed a substantially greater LV compliance in G(21−34) compared with G(50−64) and G(≥65), resulting in greater LV volume changes with preload manipulations. Although LV chamber compliance in G(50−64) and G(≥65) appeared identical, pressure–volume curves were shifted leftward, toward a decreased distensibility, with increasing age. These results suggest that LV stiffening in healthy ageing occurs during the transition between youth and middle-age and becomes manifest between the ages of 50 to 64. Thereafter, this LV stiffening is followed by LV volume contraction and remodelling after the age of 65.
Naoki Fujimoto; Jeffrey L Hastings; Paul S Bhella; Shigeki Shibata; Nainesh K Gandhi; Graeme Carrick-Ranson; Dean Palmer; Benjamin D Levine
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-02-13
Journal Detail:
Title:  The Journal of physiology     Volume:  590     ISSN:  1469-7793     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-25     Completed Date:  2012-11-07     Revised Date:  2014-05-14    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1871-80     Citation Subset:  IM    
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MeSH Terms
Aging / physiology*
Blood Pressure / physiology
Cardiac Catheterization / methods
Cohort Studies
Compliance / physiology
Diastole / physiology
Echocardiography / methods
Heart / physiology*
Heart Rate / physiology
Middle Aged
Pulmonary Wedge Pressure / physiology
Stroke Volume / physiology
Ventricular Function, Left / physiology
Young Adult
Grant Support
AG17479-02/AG/NIA NIH HHS; R01 AG017479/AG/NIA NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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