Document Detail

Effect of aerobic exercise on tumor physiology in an animal model of human breast cancer.
MedLine Citation:
PMID:  19959769     Owner:  NLM     Status:  MEDLINE    
Recent epidemiologic studies report that regular exercise may be associated with substantial reductions in cancer-specific and all-cause mortality following a breast cancer diagnosis. The mechanisms underlying this relationship have not been identified. We investigated the effects of long-term voluntary wheel running on growth and progression using an animal model of human breast cancer. We also examined effects on the central features of tumor physiology, including markers of tumor blood perfusion/vascularization, hypoxia, angiogenesis, and metabolism. Athymic female mice fed a high-fat diet were orthotopically (direct into the mammary fat pad) implanted with human breast cancer cells (MDA-MB-231 at 1 x 10(6)) into the right dorsal mammary fat pad and randomly assigned (1:1) to voluntary wheel running (n = 25) or a nonintervention (sedentary) control group (n = 25). Tumor volume was measured every three days using digital calipers. All experimental animals were killed when tumor volume reached > or = 1,500 mm(3). Kaplan-Meier (KM) analysis indicated that tumor growth (survival) was comparable between the experimental groups (exercise 44 days vs. control 48 days; KM proportional hazard ratio = 1.41, 95% confidence interval, 0.77-2.58, P = 0.14). However, tumors from exercising animals had significantly improved blood perfusion/vascularization relative to the sedentary control group (P < 0.05). Histological analyses indicated that intratumoral hypoxia levels (as assessed by hypoxia-inducible factor 1) were significantly higher in the exercise group relative to sedentary control (P < 0.05). Aerobic exercise can significantly increase intratumoral vascularization, leading to "normalization" of the tissue microenvironment in human breast tumors. Such findings may have important implications for inhibiting tumor metastasis and improving the efficacy of conventional cancer therapies.
Lee W Jones; Benjamin L Viglianti; Jessica A Tashjian; Sejal M Kothadia; Stephen T Keir; Stephen J Freedland; Michael Q Potter; Eui Jung Moon; Thies Schroeder; James E Herndon; Mark W Dewhirst
Related Documents :
18396259 - Effects of charcoal kiln saunas (jjimjilbang) on psychological states.
1758289 - The vo2max of recreational athletes before and after pregnancy.
15093569 - Physical exercise results in the improved subjective well-being of a few or is effectiv...
17061749 - Exercise and pregnancy outcome among urban, low-income, black women.
20931309 - Exercise interventions for cancer survivors: a meta-analysis of quality of life outcomes.
16954949 - Effect of esophageal ligation on small intestinal development in normal and growth-reta...
1555329 - Impedance measurement during air and helium-oxygen breathing before and after salbutamo...
7264239 - Age-related changes of cardiac control function in man. with special reference to heart...
18755679 - Moving with the beat: heart rate and visceral temperature of free-swimming and feeding ...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-12-03
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  108     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-04-23     Revised Date:  2014-09-11    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  343-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anoxia / physiopathology
Blotting, Western
Body Weight / physiology
Breast Neoplasms / blood supply,  metabolism,  pathology*
Cell Line, Tumor
Disease Progression
Energy Metabolism / physiology
Kaplan-Meier Estimate
Mice, Nude
Neoplasm Transplantation
Neoplasms, Experimental / pathology
Neovascularization, Pathologic / pathology
Physical Conditioning, Animal / physiology*
Regional Blood Flow / physiology
Survival Analysis
Tumor Markers, Biological / metabolism
Grant Support
Reg. No./Substance:
0/Tumor Markers, Biological
Erratum In:
J Appl Physiol. 2010 Apr;108(4):1021

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effects of excess corticosterone on LKB1 and AMPK signaling in rat skeletal muscle.
Next Document:  Distributed lag and spline modeling for predicting energy expenditure from accelerometry in youth.