Document Detail

Effect of acute high-intensity interval exercise on postexercise biventricular function in mild heart failure.
MedLine Citation:
PMID:  21088202     Owner:  NLM     Status:  MEDLINE    
We studied the acute effect of high-intensity interval exercise on biventricular function using cardiac magnetic resonance imaging in nine patients [age: 49 ± 16 yr; left ventricular (LV) ejection fraction (EF): 35.8 ± 7.2%] with nonischemic mild heart failure (HF). We hypothesized that a significant impairment in the immediate postexercise end-systolic volume (ESV) and end-diastolic volume (EDV) would contribute to a reduction in EF. We found that immediately following acute high-intensity interval exercise, LV ESV decreased by 6% and LV systolic annular velocity increased by 21% (both P < 0.05). Thirty minutes following exercise (+30 min), there was an absolute increase in LV EF of 2.4% (P < 0.05). Measures of preload, left atrial volume and LV EDV, were reduced immediately following exercise. Similar responses were observed for right ventricular volumes. Early filling velocity, filling rate, and diastolic annular velocity remained unchanged, while LV untwisting rate increased 24% immediately following exercise (P < 0.05) and remained 18% above baseline at +30 min (P < 0.05). The major novel findings of this investigation are 1) that acute high-intensity interval exercise decreases the immediate postexercise LV ESV and increases LV EF at +30 min in patients with mild HF, and this is associated with a reduction in LV afterload and maintenance of contractility, and 2) that despite a reduction in left atrial volume and LV EDV immediately postexercise, diastolic function is preserved and may be modulated by enhanced LV peak untwisting rate. Acute high-intensity interval exercise does not impair postexercise biventricular function in patients with nonischemic mild HF.
Corey R Tomczak; Richard B Thompson; Ian Paterson; Felix Schulte; June Cheng-Baron; Robert G Haennel; Mark J Haykowsky
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-11-18
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  110     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-09     Completed Date:  2011-06-07     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  398-406     Citation Subset:  IM    
Faculty of Rehabilitation Medicinem, 3-48 Corbett Hall, Univ. of Alberta, Edmonton, AB, Canada, T6G 2G4.
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MeSH Terms
Exercise Therapy / methods*
Heart Failure / complications,  physiopathology*,  rehabilitation*
Middle Aged
Physical Endurance*
Physical Exertion
Stroke Volume
Ventricular Dysfunction, Left / etiology,  physiopathology*,  rehabilitation*
Ventricular Function, Left*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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