| Effect of acoustic power on in vivo molecular imaging with targeted microbubbles: implications for low-mechanical index real-time imaging. | |
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MedLine Citation:
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PMID: 19910159 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The aim of this study was to evaluate the influence of acoustic power on ultrasound molecular imaging data with targeted microbubbles. METHODS: Imaging was performed with a contrast-specific multipulse method at mechanical indexes (MIs) of 0.18 and 0.97. In vitro imaging was used to measure concentration-intensity relationships and to assess whether damping from microbubble attachment to cultured endothelial cells affected signal enhancement. Power-related differences in signal enhancement were evaluated in vivo by P-selectin-targeted and control microbubble imaging in a murine model of hind-limb ischemia-reperfusion injury. RESULTS: During in vitro experiments, there was minimal acoustic damping from microbubble-cell attachment at either MI. Signal enhancement in the in vitro and in vivo experiments was 2-fold to 3-fold higher for high-MI imaging compared with low-MI imaging, which was due to greater pixel intensity, the detection of a greater number of retained microbubbles, and increased point-spread function. Yet there was a linear relationship between high-MI and low-MI data indicating that the relative degree of enhancement was similar. CONCLUSION: During molecular imaging, high-MI protocols produce more robust targeted signal enhancement than low-MI protocols, although differences in relative enhancement caused by condition or agent are similar. |
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Authors:
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Beat A Kaufmann; Chad L Carr; Todd Belcik; Aris Xie; Benjamin Kron; Qi Yue; Jonathan R Lindner |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-11-11 |
Journal Detail:
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Title: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography Volume: 23 ISSN: 1097-6795 ISO Abbreviation: J Am Soc Echocardiogr Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-02-03 Completed Date: 2010-05-03 Revised Date: 2012-04-02 |
Medline Journal Info:
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Nlm Unique ID: 8801388 Medline TA: J Am Soc Echocardiogr Country: United States |
Other Details:
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Languages: eng Pagination: 79-85 Citation Subset: IM |
Affiliation:
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Cardiovascular Division, Oregon Health & Science University, Portland, Oregon 97239, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cells, Cultured Computer Systems Contrast Media* Drug Delivery Systems / methods Endothelial Cells / ultrasonography* Energy Transfer Mice Microbubbles* Radiation Dosage Reperfusion Injury / ultrasonography* Reproducibility of Results Sensitivity and Specificity Ultrasonography / methods* |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL078610-05/HL/NHLBI NIH HHS; R01 HL078610-06/HL/NHLBI NIH HHS; R01 HL078610-09/HL/NHLBI NIH HHS; R01-DK063508/DK/NIDDK NIH HHS; R01-HL074443/HL/NHLBI NIH HHS; R01-HL078610/HL/NHLBI NIH HHS; RC1 HL100659-01/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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