| Effect of Acanthopanax senticosus on 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe of exercised rats. | |
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MedLine Citation:
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PMID: 17826016 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acanthopanax senticosus Harms (AS) is classified into the family of Araliaceae. The plant has been used as an analeptic aid, which improves weakened physical status and strength. Serotonin (5-hydroxytryptamine, 5-HT) is an important neurotransmitter and tryptophan hydroxylase (TPH) catalyzes the rate-f the raphe nuclei. These are associated with "central fatigue hypotheses" in the brain. In the present study, the effects of Acanthopanax senticosus on the time to exhaustion by treadmill exercise and on 5-HT synthesis and TPH expression in the dorsal raphe were investigated by immunohistochemistry. In the present results, Acanthopanax senticosus increased the time to exhaustion by treadmill running and it suppressed the exercise-induced increase of 5-HT synthesis and TPH expression. Acanthopanax senticosus was effective as caffeine for increasing the exhaustion time in treadmill running and for reducing the exercise-induced increase of 5-HT synthesis and TPH expression in the dorsal raphe. The present study shows that Acanthopanax senticosus reduces fatigue during exercise by the inhibition of exercise-induced 5-HT synthesis and TPH expression in the dorsal raphe. |
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Authors:
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Yong-Taek Rhim; Hong Kim; Sung-Jin Yoon; Sung-Soo Kim; Hyun-Kyung Chang; Taeck-Hyun Lee; Hee-Hyuk Lee; Min-Chul Shin; Mal-Soon Shin; Chang-Ju Kim |
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Publication Detail:
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Type: Journal Article Date: 2007-08-03 |
Journal Detail:
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Title: Journal of ethnopharmacology Volume: 114 ISSN: 0378-8741 ISO Abbreviation: J Ethnopharmacol Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-09-28 Completed Date: 2008-01-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7903310 Medline TA: J Ethnopharmacol Country: Ireland |
Other Details:
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Languages: eng Pagination: 38-43 Citation Subset: IM |
Affiliation:
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Department of Exercise Physiology, Graduate School, Korea University, #1 5-Ka Anam-dong, Sungbuk-gu, Seoul 136-701, South Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acanthopanax
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chemistry* Animals Dose-Response Relationship, Drug Exercise Test Fatigue / drug therapy Gene Expression Regulation, Enzymologic / drug effects* Male Physical Conditioning, Animal / physiology Plant Extracts / administration & dosage, pharmacology* Raphe Nuclei / drug effects, metabolism Rats Rats, Sprague-Dawley Serotonin / biosynthesis Tryptophan Hydroxylase / drug effects*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Plant Extracts; 50-67-9/Serotonin; EC 1.14.16.4/Tryptophan Hydroxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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