| Effect of ATP synthesis promoters on postischemic myocardial recovery. | |
| | |
MedLine Citation:
|
PMID: 2395365 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The use of cardioplegia during surgically induced ischemia greatly reduces myocardial metabolic requirements. However, adenosine triphosphate (ATP) depletion may occur, resulting in poor functional recovery after ischemia. This study investigated if augmentation of intracellular ATP could be achieved by delivering known ATP synthesis promoters (adenosine and/or phosphate) during cardioplegic arrest, and whether this could enhance myocardial functional and metabolic recovery following ischemia. Isolated, perfused rabbit hearts were subjected to 120 min of hypothermic (34 degrees C) cardioplegia-induced ischemia. Controls received St. Thomas cardioplegia (CTL); remaining hearts received cardioplegia containing 200 microM adenosine (ADO), or 25 microM phosphate (PO4), or both ADO and PO4. Following ischemia and reperfusion, recovery of developed pressure (%DP) and postischemic diastolic stiffness was significantly better in adenosine hearts when compared with control or PO4 hearts. To determine if ADO or PO4 minimized depletion of ATP during ischemia or accelerated synthesis of ATP in the postischemic period, nucleotide levels were obtained before, during, and after ischemia. During ischemia, ATP fell equally in all groups, indicating that ADO and PO4 did not alter ischemia-induced depletion of ATP. However, intracellular adenosine was augmented during ischemia in adenosine-treated hearts. Consequently, during reperfusion, ADO and ADO/PO4 hearts had significantly enhanced ATP levels, suggesting that augmenting myocardial adenosine accelerated synthesis of ATP postischemia. The addition of phosphate, a stimulus for ATP synthesis, did not augment postischemic ATP. In fact, the beneficial effect of adenosine may have been decreased when phosphate was added to adenosine. In conclusion, adenosine but not PO4 augments intracellular ATP by allowing better metabolic repletion following ischemia, thereby improving postischemic myocardial functional recovery. |
| | |
Authors:
|
S F Bolling; L E Bies; E L Bove |
Related Documents
:
|
7850665 - Effects of modified st thomas' hospital solution on coronary artery endothelium depende... 1426935 - Effect of atp and verapamil as cardioplegic additives in the isolated guinea pig heart. 8303695 - Warm blood cardioplegia for patients undergoing revascularization for left main coronar... 1764835 - Contrast echocardiography and myocardial perfusion. 2650875 - Diuretics in congestive heart failure. 6782595 - Precordial thump in the treatment of cardiac arrhythmias (electrophysiologic considerat... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Journal of surgical research Volume: 49 ISSN: 0022-4804 ISO Abbreviation: J. Surg. Res. Publication Date: 1990 Sep |
Date Detail:
|
Created Date: 1990-10-05 Completed Date: 1990-10-05 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 0376340 Medline TA: J Surg Res Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 205-11 Citation Subset: IM |
Affiliation:
|
Section of Thoracic Surgery, University of Michigan Medical Center, Ann Arbor 48109. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenosine
/
pharmacology* Adenosine Triphosphate / biosynthesis* Animals Diastole Heart Arrest, Induced* Male Myocardial Reperfusion Myocardium / metabolism* Phosphates / pharmacology* Rabbits Ventricular Function |
| Chemical | |
Reg. No./Substance:
|
0/Phosphates; 56-65-5/Adenosine Triphosphate; 58-61-7/Adenosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Analytical study of open four compartment pharmacokinetic models: concentrations, area under curves,...
Next Document: Ventriculoarterial coupling influences regional contractility.