Document Detail

Effect of ADA(1) mother-fetus and wife-husband phenotypic differences on the ratio birth weight/placental weight in fertile women and on reproductive success in couples with RSA.
MedLine Citation:
PMID:  22287124     Owner:  NLM     Status:  Publisher    
OBJECTIVES: To study the effect Adenosine Deaminase locus 1 (ADA(1) ) mother-fetus and wife-husband phenotypic differences on the ratio Birth Weight/Placental Weight (BW/PW) in fertile women and on reproductive success in couples with repeated spontaneous abortion (RSA). METHODS: 209 couples with primary RSA and a consecutive series of 379 healthy puerperae with their newborn infants from the White Caucasian population of central Italy were studied. In primary RSA women reproductive success was indicated by the presence of at least one live-born infant within 5 years of follow up. Two way contingency tables were analyzed by chi-square. RESULTS: The proportion of primary RSA couples with at least a live-born infant shows the highest value in couples mother ADA(1) 1/father carrier of ADA(1) *2 allele (55.2%) and the lowest value in reciprocal couples mother carrier of ADA(1) *2 allele /father ADA(1) 1 (18.7 %) (O.R. = 5.33; P = 0.023). The highest ratio BW/PW is observed in the class mother ADA(1) 1/newborn carrier of ADA(1) *2 allele while the lowest ratio is observed in the reciprocal class mother carrier of ADA(1) *2 allele/ newborn ADA(1) 1. CONCLUSIONS: Differences between mother and fetus in ADA(1) phenotype may influence the ratio BW/PW in healthy women and reproductive success in RSA women. Am. J. Hum. Biol. © 2012Wiley Periodicals, Inc.
Fulvia Gloria-Bottini; Maria Nicotra; Ada Amante; Sara Ambrosi; Eliana Cozzoli; Patrizia Saccucci; Egidio Bottini; Andrea Magrini
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-27
Journal Detail:
Title:  American journal of human biology : the official journal of the Human Biology Council     Volume:  -     ISSN:  1520-6300     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8915029     Medline TA:  Am J Hum Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Division of Human Populations Biopathology and Environmental Pathology, Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, School of Medicine, Rome, Italy.
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