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Effect of an 8-Weeks Aerobic Training Program in Elderly on Oxidative Stress and HSP72 Expression in Leukocytes during Antioxidant Supplementation.
MedLine Citation:
PMID:  22323351     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Objective: To investigate the effect of aerobic training in the context of antioxidant supplementation on systemic oxidative stress and leukocytes heat shock protein (Hsp)72 expression in the elderly. Design: Sixteen septuagenarians (8 males and 8 females, mean age 74.6) were supplemented with Vitamin C and E (respectively 500 and 100mg per day) and randomly assigned either to sedentary (AS) or individualized aerobically trained (AT) group for 8 weeks. Methods: Plasma Vitamin C and E concentrations and aerobic fitness, as well as resting and post graded exercise (GXT) Hsp72 expression in leukocytes, plasma levels of thiobarbituric acid reactive substances (TBARS) and advanced oxidation protein product (AOPP) were measured pre and post training / supplementation. Results: At the end of the intervention, the two groups showed a significant increase in resting plasma vitamin C and E (approximately 50 and 20% increase respectively) and a significant decrease in both resting and post GXT plasma TBARS and AOPP (approximately 25 and 20% decrease respectively). These changes were of similar magnitude in the two groups. The reduced oxidative stress was concomitant with a 15% decreased expression of Hsp72 in monocytes and granulocytes in both groups. Conclusion: This study provides evidence that in elderly, increased concentration of antioxidant vitamins C and E is associated with a reduction in oxidative stress and leukocytes Hsp72. In this context, 8 weeks of aerobic training has no impact on oxidative stress or leukocytes Hsp72 expression in elderly people.
Authors:
D Simar; D Malatesta; E Mas; M Delage; C Caillaud
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The journal of nutrition, health & aging     Volume:  16     ISSN:  1760-4788     ISO Abbreviation:  J Nutr Health Aging     Publication Date:  2012  
Date Detail:
Created Date:  2012-02-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100893366     Medline TA:  J Nutr Health Aging     Country:  France    
Other Details:
Languages:  eng     Pagination:  155-61     Citation Subset:  IM    
Affiliation:
D. Simar, School of Medical Science, Faculty of Medicine, University of New South Wales, Wallace Wurth Building, Sydney NSW 2052, Australia - Tel: (61) 293858142 - Fax: (61) 293851551 Email d.simar@unsw.edu.au.
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