| Effect of 8-O-acetyl shanzhiside methylester increases angiogenesis and improves functional recovery after stroke. | |
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MedLine Citation:
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PMID: 20735376 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated whether 8-O-acetyl shanzhiside methylester (ND01) regulates angiogenesis and thereby improves functional outcome after stroke. Adult male rats were subjected to 1 hr of middle cerebral artery occlusion (MCAO) and reperfusion, and treated with or without different doses (5 and 10 mg/kg) of ND01, starting 24 hr after ischaemia and reperfusion (I/R) and by intravenous injection daily for 14 days. Neurological functional tests were performed and cerebral Evans blue extravasation was measured. Angiogenesis and angiogenic factor expression were measured by immunohistochemistry and Western blot, respectively. The results indicated that ND01 significantly promoted angiogenesis in the ischaemic brain and improved functional outcome after stroke. ND01 also significantly increased vascularization compared with vehicle treatment. ND01 increased the expression of VEGF, Ang1, phosphorylation of Tie2 and Akt VEGF. The Ang1/Tie2 axis and Akt pathways appear to mediate ND01-induced angiogenesis. |
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Authors:
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Wang-Lin Jiang; Shu-Ping Zhang; Hai-Bo Zhu; Jian Hou |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Basic & clinical pharmacology & toxicology Volume: 108 ISSN: 1742-7843 ISO Abbreviation: Basic Clin. Pharmacol. Toxicol. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-16 Completed Date: 2011-01-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101208422 Medline TA: Basic Clin Pharmacol Toxicol Country: Denmark |
Other Details:
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Languages: eng Pagination: 21-7 Citation Subset: IM |
Copyright Information:
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© 2010 The Authors. Basic & Clinical Pharmacology & Toxicology © 2010 Nordic Pharmacological Society. |
Affiliation:
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College of Pharmacy and Institute of Material Medica, Binzhou Medical University, Yantai, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiogenesis Inducing Agents
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therapeutic use* Angiogenic Proteins / metabolism Animals Blood-Brain Barrier / drug effects, metabolism Brain / blood supply, drug effects, metabolism Glucosides / therapeutic use* Humans Male Pyrans / therapeutic use* Rats Rats, Sprague-Dawley Stroke / drug therapy*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Angiogenesis Inducing Agents; 0/Angiogenic Proteins; 0/Glucosides; 0/Pyrans; 57420-46-9/8-O-acetyl shanzhiside methyl ester |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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