Document Detail

Effect of 6-wk estrogen withdrawal or replacement on myocardial ischemic tolerance in rats.
MedLine Citation:
PMID:  10749694     Owner:  NLM     Status:  MEDLINE    
Menopausal status is a risk factor for coronary artery disease death, but the mechanism underlying this association is uncertain. To test whether estrogen ameliorates the effects of acute myocardial ischemia in ways likely to translate into a mortality difference, we compared the response to brief (6-min) and prolonged (45-min) coronary occlusion in vivo in five groups (each n = 16) of rats: ovariectomized females; ovariectomized females after 6 wk 17beta-estradiol replacement; male rats supplemented with estradiol for 6 wk; normal males; and normal females. Coronary occlusion produced a uniform ischemic risk area averaging 53 +/- 3% of left ventricular volume. After a brief occlusion, reperfusion ventricular tachycardia/fibrillation occurred with >85% frequency in all groups. During a prolonged occlusion, ischemic ventricular tachycardia occurred in 100% and sustained tachycardia requiring cardioversion in >75% of rats in all groups. Myocardial infarct size averaged 52 +/- 4% of the ischemic risk area and was similarly unaffected by gender or estrogen status. We conclude that neither short-term estrogen withdrawal, replacement, nor supplementation significantly affects the potentially lethal outcomes from acute coronary occlusion in this species.
P H McNulty; D Jagasia; J M Whiting; T Caulin-Glaser
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  278     ISSN:  0363-6135     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-04-27     Completed Date:  2000-04-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H1030-4     Citation Subset:  IM    
Section of Cardiovascular Medicine, Veterans Affairs Connecticut Medical Center and Yale University School of Medicine, New Haven, Connecticut 06520, USA.
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MeSH Terms
Coronary Disease / blood,  drug therapy,  pathology
Estradiol / blood,  deficiency*,  pharmacology*
Menopause / physiology
Myocardial Infarction / blood,  drug therapy,  pathology
Myocardial Ischemia / blood,  drug therapy*,  pathology
Myocardial Reperfusion Injury / blood,  drug therapy,  pathology
Rats, Sprague-Dawley
Risk Assessment
Sex Factors
Tachycardia, Ventricular / blood
Ventricular Fibrillation / blood
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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