| Effect of 6 months of exercise and isoflavone supplementation on clinical cardiovascular risk factors in obese postmenopausal women: a randomized, double-blind study. | |
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MedLine Citation:
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PMID: 17290158 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate whether 6 months of exercise combined with isoflavone supplementation could improve clinical risk factors that predispose to cardiovascular disease in obese postmenopausal women. DESIGN: This was a randomized, double-blind, controlled trial in which 50 healthy obese postmenopausal women were divided into two groups and assigned to isoflavone supplementation (n=25) or a placebo (n=25) for 1 year. For the last 6 months, both groups participated in an exercise program (three times per week), at the end of which cardiovascular disease risk factors were compared between groups. Body composition (using dual-energy x-ray absorptiometry), metabolic profile (blood lipids, fasting insulin, fasting glucose, sex hormone-binding globulin, C-reactive protein) were determined at baseline and at 6 and 12 months. RESULTS: We observed a significant effect of exercise and isoflavone supplementation on body weight, total and abdominal fat mass (kilograms and percentage), body mass index, appendicular fat-free mass, fat-free mass/fat mass ratio, and sex hormone-binding globulin, but not with exercise alone. No difference was observed for other biochemical characteristics, although the quantitative insulin sensitivity check index increased equally in both groups. Conversely, although not significant, we observed a tendency for a treatment effect on body mass index (P=0.07) and on absolute (kilograms) (P=0.07) and percentage of (P=0.053) abdominal fat mass, whereas no effect of treatment was found for other variables using the Mann-Whitney test. CONCLUSIONS: Compared to an aerobic exercise program alone, 70 mg/day of isoflavones combined with exercise may promote significant improvements in body composition parameters that are known to influence cardiovascular disease risk in postmenopausal women. |
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Authors:
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Mylène Aubertin-Leheudre; Christine Lord; Abdelouahed Khalil; Isabelle J Dionne |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Menopause (New York, N.Y.) Volume: 14 ISSN: 1072-3714 ISO Abbreviation: Menopause Publication Date: 2007 Jul-Aug |
Date Detail:
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Created Date: 2007-07-10 Completed Date: 2007-08-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9433353 Medline TA: Menopause Country: United States |
Other Details:
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Languages: eng Pagination: 624-9 Citation Subset: IM |
Affiliation:
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Research Centre on Aging, Sherbrooke, QC, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Blood Glucose Body Composition Cardiovascular Diseases / etiology, prevention & control Cholesterol, HDL / blood Cholesterol, LDL / blood Dietary Supplements Double-Blind Method Exercise* Female Humans Insulin / blood Isoflavones / administration & dosage* Middle Aged Obesity / blood, drug therapy, therapy* Phytotherapy* Plant Extracts / administration & dosage Postmenopause Risk Factors Soybeans* Treatment Outcome Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Isoflavones; 0/Plant Extracts; 0/Triglycerides; 11061-68-0/Insulin |
| Comments/Corrections | |
Comment In:
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Menopause. 2007 Jul-Aug;14(4):606-8
[PMID:
17507831
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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