Document Detail


Effect of 5-iodo-5'-amino-2',5'-dideoxyuridine on varicella-zoster virus in vitro.
MedLine Citation:
PMID:  224809     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The antiviral effect of the nucleoside analog 5-iodo-5'-amino-2',5'-dideoxyuridine (AIU) was tested with three isolates of varicella-zoster virus (VZV). AIU concentrations of 10 to 800 muM (3.5 to 288 mug/ml) reduced the number of plaques produced by VZV-infected cells and cell-free VZV from approximately 30 to 95%. Smaller plaque size was also observed in the presence of AIU. AIU was less effective than arabinofuranosylthymine in reducing VZV-induced plaques since as little as 5 mug of arabinofuranosylthymine per ml completely blocked plaque formation by cell-free VZV. Toxicity assays with human diploid embryo fibroblast cells were also carried out. Drug concentrations as high as 800 muM were not toxic to human diploid embryo fibroblast cells as determined by radiolabeling of cell deoxyribonucleic acid, ribonucleic acid, and protein.
Authors:
J P Iltis; T S Lin; W H Prusoff; F Rapp
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  16     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  1979 Jul 
Date Detail:
Created Date:  1979-10-24     Completed Date:  1979-10-24     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  92-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Arabinonucleosides / pharmacology
Cells, Cultured
DNA, Viral / biosynthesis
Diploidy
Embryo, Mammalian
Fibroblasts / drug effects
Herpesvirus 3, Human / drug effects*,  growth & development
Humans
Idoxuridine / analogs & derivatives*,  pharmacology
Plaque Assay
RNA, Viral / biosynthesis
Thymidine / pharmacology
Viral Proteins / biosynthesis
Virus Replication / drug effects
Chemical
Reg. No./Substance:
0/Arabinonucleosides; 0/DNA, Viral; 0/RNA, Viral; 0/Viral Proteins; 50-89-5/Thymidine; 54-42-2/Idoxuridine
Comments/Corrections

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