Document Detail


Effect of 5-aminosalicylic acid (5-ASA) and other salicylates on short-chain fat metabolism in the colonic mucosa. Pharmacological implications for ulcerative colitis.
MedLine Citation:
PMID:  2867767     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
5-Aminosalicylic acid (5-ASA) suppressed nitrite-stimulated oxidation of the fatty acid n-butyrate in a dose-dependent manner in isolated human and rat colonic epithelial cells. 4-ASA had one-sixth of the capacity of 5-ASA and sulphapyridine (SP) little of the capacity of 5-ASA to suppress fatty acid oxidation in human colonic epithelial cells. Sulphasalazine (SASP), azodisalicylic acid (ADS), acetyl-5-ASA and acetyl salicylic acid (ASA) did not suppress fatty acid oxidation in rat colonocytes. The suppression index of fatty acid oxidation (SIFO) of respective salicylic acids correlated with the reported clinical effectiveness of each drug against ulcerative colitis (UC). The capacity of 5-ASA to affect nitrite-stimulated oxidation of fat in the colonic mucosa suggests that nitrite ions and control of fatty acid oxidation play a central role in the development and therapy of active UC.
Authors:
W Roediger; G Schapel; M Lawson; B Radcliffe; S Nance
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical pharmacology     Volume:  35     ISSN:  0006-2952     ISO Abbreviation:  Biochem. Pharmacol.     Publication Date:  1986 Jan 
Date Detail:
Created Date:  1986-02-17     Completed Date:  1986-02-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0101032     Medline TA:  Biochem Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  221-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aminosalicylic Acids / pharmacology*
Animals
Cells, Cultured
Colon / metabolism*
Fatty Acids / metabolism*
Female
Humans
Intestinal Mucosa / metabolism
Male
Mesalamine
Nitrites / pharmacology
Oxidation-Reduction
Rats
Salicylates / pharmacology*
Structure-Activity Relationship
Sulfapyridine / pharmacology
Sulfasalazine / pharmacology
Chemical
Reg. No./Substance:
0/Aminosalicylic Acids; 0/Fatty Acids; 0/Nitrites; 0/Salicylates; 144-83-2/Sulfapyridine; 599-79-1/Sulfasalazine; 89-57-6/Mesalamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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