| Effect of 5-aminosalicylic acid (5-ASA) and other salicylates on short-chain fat metabolism in the colonic mucosa. Pharmacological implications for ulcerative colitis. | |
| | |
MedLine Citation:
|
PMID: 2867767 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
5-Aminosalicylic acid (5-ASA) suppressed nitrite-stimulated oxidation of the fatty acid n-butyrate in a dose-dependent manner in isolated human and rat colonic epithelial cells. 4-ASA had one-sixth of the capacity of 5-ASA and sulphapyridine (SP) little of the capacity of 5-ASA to suppress fatty acid oxidation in human colonic epithelial cells. Sulphasalazine (SASP), azodisalicylic acid (ADS), acetyl-5-ASA and acetyl salicylic acid (ASA) did not suppress fatty acid oxidation in rat colonocytes. The suppression index of fatty acid oxidation (SIFO) of respective salicylic acids correlated with the reported clinical effectiveness of each drug against ulcerative colitis (UC). The capacity of 5-ASA to affect nitrite-stimulated oxidation of fat in the colonic mucosa suggests that nitrite ions and control of fatty acid oxidation play a central role in the development and therapy of active UC. |
| | |
Authors:
|
W Roediger; G Schapel; M Lawson; B Radcliffe; S Nance |
Related Documents
:
|
2116497 - Inhibition of mitochondrial carnitine acylcarnitine translocase by hypoglycaemia-induci... 3827937 - Effect of methylglyoxal bis(guanylhydrazone) on hepatic, heart and skeletal muscle mito... 3933547 - Reactions of proteins with oxidizing lipids. 1. analytical measurements of lipid oxidat... 2002347 - Postnatal development and isolation of peroxisomes from brain. 18972057 - Synthesis of 11-thialinoleic acid and 14-thialinoleic acid, inhibitors of soybean and h... 15083757 - Food and fatty acid intake and atopic disease in adults. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Biochemical pharmacology Volume: 35 ISSN: 0006-2952 ISO Abbreviation: Biochem. Pharmacol. Publication Date: 1986 Jan |
Date Detail:
|
Created Date: 1986-02-17 Completed Date: 1986-02-17 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0101032 Medline TA: Biochem Pharmacol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 221-5 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aminosalicylic Acids
/
pharmacology* Animals Cells, Cultured Colon / metabolism* Fatty Acids / metabolism* Female Humans Intestinal Mucosa / metabolism Male Mesalamine Nitrites / pharmacology Oxidation-Reduction Rats Salicylates / pharmacology* Structure-Activity Relationship Sulfapyridine / pharmacology Sulfasalazine / pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Aminosalicylic Acids; 0/Fatty Acids; 0/Nitrites; 0/Salicylates; 144-83-2/Sulfapyridine; 599-79-1/Sulfasalazine; 89-57-6/Mesalamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Polyamines appear to be second messengers in mediating Ca2+ fluxes and neurotransmitter release in p...
Next Document: Mechanism of S-(1,2-dichlorovinyl)glutathione-induced nephrotoxicity.