Document Detail

Effect of 5-aminosalicylic acid (5-ASA) and other salicylates on short-chain fat metabolism in the colonic mucosa. Pharmacological implications for ulcerative colitis.
MedLine Citation:
PMID:  2867767     Owner:  NLM     Status:  MEDLINE    
5-Aminosalicylic acid (5-ASA) suppressed nitrite-stimulated oxidation of the fatty acid n-butyrate in a dose-dependent manner in isolated human and rat colonic epithelial cells. 4-ASA had one-sixth of the capacity of 5-ASA and sulphapyridine (SP) little of the capacity of 5-ASA to suppress fatty acid oxidation in human colonic epithelial cells. Sulphasalazine (SASP), azodisalicylic acid (ADS), acetyl-5-ASA and acetyl salicylic acid (ASA) did not suppress fatty acid oxidation in rat colonocytes. The suppression index of fatty acid oxidation (SIFO) of respective salicylic acids correlated with the reported clinical effectiveness of each drug against ulcerative colitis (UC). The capacity of 5-ASA to affect nitrite-stimulated oxidation of fat in the colonic mucosa suggests that nitrite ions and control of fatty acid oxidation play a central role in the development and therapy of active UC.
W Roediger; G Schapel; M Lawson; B Radcliffe; S Nance
Related Documents :
20132857 - Metabolic remodeling associated with subchronic doxorubicin cardiomyopathy.
5684037 - The metabolism of chylomicron fatty acids by isolated rat heart-lung preparations.
7201097 - Kinetics of carnitine-dependent fatty acid oxidation: implications for human carnitine ...
8486647 - Induction of peroxisomal fatty acid beta-oxidation and liver fatty acid-binding protein...
698237 - The lipid composition of isolated rat spermatids and spermatocytes.
3684387 - Uterine metabolism of the conscious gilt during late pregnancy.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical pharmacology     Volume:  35     ISSN:  0006-2952     ISO Abbreviation:  Biochem. Pharmacol.     Publication Date:  1986 Jan 
Date Detail:
Created Date:  1986-02-17     Completed Date:  1986-02-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0101032     Medline TA:  Biochem Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  221-5     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aminosalicylic Acids / pharmacology*
Cells, Cultured
Colon / metabolism*
Fatty Acids / metabolism*
Intestinal Mucosa / metabolism
Nitrites / pharmacology
Salicylates / pharmacology*
Structure-Activity Relationship
Sulfapyridine / pharmacology
Sulfasalazine / pharmacology
Reg. No./Substance:
0/Aminosalicylic Acids; 0/Fatty Acids; 0/Nitrites; 0/Salicylates; 144-83-2/Sulfapyridine; 599-79-1/Sulfasalazine; 89-57-6/Mesalamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Polyamines appear to be second messengers in mediating Ca2+ fluxes and neurotransmitter release in p...
Next Document:  Mechanism of S-(1,2-dichlorovinyl)glutathione-induced nephrotoxicity.