Document Detail

Effect of 4-hydroxynonenal on c-myc expression.
MedLine Citation:
PMID:  3475758     Owner:  NLM     Status:  MEDLINE    
The 4-hydroxynonenal aldehyde (HNE), a product of lipid peroxidation with high biological activity, inhibits cancerous growths in vivo and in vitro. The mechanism by which this aldehyde acts is not yet understood. The c-myc oncogene seems to be involved in the regulation of cellular multiplication and transformation. We evaluated the c-myc expression and the RNA, DNA and protein synthesis in K562 cells. These cells were incubated for 1 hour in presence of several aldehyde concentrations (range 5.10(-7) to 10(-4)), then washed and kept for 20 hours in a growth medium until used. HNE inhibited both the nucleic acids and protein synthesis in a dose dependent manner, and c-myc expression was evaluated in the K562 cells after incubation with 10(-4) M or 10(-6) M HNE. HNE inhibited c-myc expression only at the highest dose. These preliminary results may suggest that the inhibition of c-myc expression is related to nucleic acid synthesis inhibition following HNE exposure.
G Barrera; S Martinotti; V Fazio; V Manzari; L Paradisi; M Parola; L Frati; M U Dianzani
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Toxicologic pathology     Volume:  15     ISSN:  0192-6233     ISO Abbreviation:  Toxicol Pathol     Publication Date:  1987  
Date Detail:
Created Date:  1987-09-22     Completed Date:  1987-09-22     Revised Date:  2009-07-01    
Medline Journal Info:
Nlm Unique ID:  7905907     Medline TA:  Toxicol Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  238-40     Citation Subset:  IM    
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MeSH Terms
Aldehydes / pharmacology*
Cell Line
DNA, Neoplasm / biosynthesis
Leukemia, Myeloid
Neoplasm Proteins / biosynthesis
Proto-Oncogenes / drug effects*
RNA, Neoplasm / biosynthesis
Reg. No./Substance:
0/Aldehydes; 0/DNA, Neoplasm; 0/Neoplasm Proteins; 0/RNA, Neoplasm; 29343-52-0/4-hydroxy-2-nonenal

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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