| Effect of 2-pyrrolidone on the concentration of GABA in rat tissues. | |
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MedLine Citation:
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PMID: 2898157 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of 2-pyrrolidone, a cyclic lactam of GABA, were studied on blood and organ levels of 2-pyrrolidone, GABA, glutamic acid, glutamate decarboxylase (GAD) and GABA-transaminase (GABA-T). When administered i.p., the only significant effects observed were increases of brain and liver 2-pyrrolidone. In contrast, regular oral administration for 7 months produced significant increases of GABA and glutamic acid in brain and of glutamic acid alone in liver while GAD decreased in brain and increased in liver; GABA-T was unchanged. A new method for the synthesis of radioactive 2-pyrrolidone was set up and the enzymatic conversion of 2-pyrrolidone to GABA was measured by an original procedure. The results obtained in vitro by this method on the conversion of 2-pyrrolidone to GABA catalyzed by tissue slices, together with the observed inhibition of the GABA-dependent oxygen consumption by 2-pyrrolidone, partially explain the effects of the oral administration. |
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Authors:
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C Fasolato; A Bertazzon; A Previero; L Galzigna |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pharmacology Volume: 36 ISSN: 0031-7012 ISO Abbreviation: Pharmacology Publication Date: 1988 |
Date Detail:
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Created Date: 1988-07-15 Completed Date: 1988-07-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0152016 Medline TA: Pharmacology Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 258-64 Citation Subset: IM |
Affiliation:
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Institute of Biological Chemistry, University of Padova, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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4-Aminobutyrate Transaminase
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metabolism Animals Brain / drug effects*, metabolism Glutamates / metabolism Glutamic Acid Liver / drug effects*, metabolism Pyrrolidinones / analysis, blood, pharmacology* Rats Rats, Inbred Strains gamma-Aminobutyric Acid / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Glutamates; 0/Pyrrolidinones; 56-12-2/gamma-Aminobutyric Acid; 56-86-0/Glutamic Acid; EC 2.6.1.19/4-Aminobutyrate Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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