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Effect of 2-(4-fluorophenylamino)-5-(2,4-dihydroxyphenyl)-1,3,4-thiadiazole on the molecular organisation and structural properties of the DPPC lipid multibilayers.
MedLine Citation:
PMID:  22835906     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Interactions and complex formation between lipids and biologically active compounds is crucial for better understanding of molecular mechanisms occurring in living cells. In this paper a molecular organization and complex formation of 2-(4-fluorophenylamino)-5-(2,4-dihydroxybenzeno)-1,3,4-thiadiazole (FABT) in DPPC multibilayers is reported. The simplified pseudo binary phase diagram of this system was created based on the X-ray diffraction study and FTIR spectroscopic data. The detailed analysis of the refraction effect indicates a much higher concentration of FABT in the polar zones during phase transition. Both the lipid and the complex ripple after cooling. It was found that FABT occupied not only the hydrophilic zones of the lipid membranes but also partly occupied the central part of the non polar zone. The FTIR study reveals that FABT strongly interact with hydrophilic (especially PO(2)(-)) and hydrophobic (especially "kink" vibrations of CH(2) group). The interactions of FABT molecules with these groups are responsible for changes of lipid multibilayers observed in X-ray diffraction study.
Authors:
Daniel M Kamiński; Arkadiusz Matwijczuk; Damian Pociecha; Ewa Górecka; Andrzej Niewiadomy; Mirosława Dmowska; Mariusz Gagoś
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-23
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  -     ISSN:  0006-3002     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
Affiliation:
Department of Chemistry, University of Life Sciences in Lublin, Akademicka 15, 20-950 Lublin, Poland; Department of Chemistry, Warsaw University 02-093 Warszawa, Pasteura 1, Poland.
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