| Effect of 17-beta-estradiol administration during adriamycin-induced cardiomyopathy in ovariectomized rat. | |
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MedLine Citation:
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PMID: 16225861 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The incidence of cardiovascular diseases in humans differs in relation to the age of the patient. Although women suffer less than men from cardiovascular disorders during 15-55 years, after this period the incidence is equivalent in both sexes. This data suggests a cytoprotective effect of estrogens against cardiovascular disease. The estrogens, especially 17-beta-estradiol, are important antioxidant molecules with potential cytoprotective properties during oxidant/antioxidant disbalance induced by oxidative stress. Oxidative stress is often the underlying mechanism during vascular alterations and cardiac damage. The present study evaluated the role of ovariectomy and/or 17-beta-estradiol administration on antioxidant status and lipid peroxidation during cardiac injury induced by adriamycin. Different parameters were measured, including hemodynamic response (arterial pressure and cardiac frequency), lipid peroxidation products (malondialdehyde), protein carbonylation, antioxidant status (reduced glutathione, glutathione peroxidase, superoxide dismutase and catalase), and cardiac injury (creatinine kinase, lactate dehydrogenase, aspartate and alanine aminotransferase). Our study showed that 17-beta-estradiol reduced all of the parameters related to oxidative stress and cardiac injury in ovariectomized rats treated with adriamycin. |
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Authors:
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Juan R Muñoz-Castañeda; Pedro Montilla; Maria C Muñoz; Inmaculada Bujalance; Jordi Muntané; Isaac Túnez |
Publication Detail:
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Type: Journal Article Date: 2005-10-12 |
Journal Detail:
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Title: European journal of pharmacology Volume: 523 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2005-10-31 Completed Date: 2006-02-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 86-92 Citation Subset: IM |
Affiliation:
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Department of Biochemistry and Molecular Biology, School of Medicine, University of Cordoba, Spain. juanr.munoz.exts@juntadeandalucia.es |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alanine Transaminase
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blood Analysis of Variance Animals Aspartate Aminotransferases / blood Blood Pressure / drug effects Cardiomyopathies / chemically induced, physiopathology, prevention & control* Catalase / metabolism Creatine Kinase / blood Disease Models, Animal Doxorubicin Estradiol / administration & dosage, pharmacology* Female Glutathione / metabolism Glutathione Peroxidase / metabolism Heart / drug effects, physiopathology Lipid Peroxidation / drug effects Myocardium / enzymology Nitric Oxide / metabolism Ovariectomy Oxidative Stress / drug effects Rats Rats, Wistar Superoxide Dismutase / metabolism |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide; 23214-92-8/Doxorubicin; 50-28-2/Estradiol; 70-18-8/Glutathione; EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase; EC 2.7.3.2/Creatine Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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