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Effect of a 16 weeks weight loss program on osteoarthritis biomarkers in obese patients with knee osteoarthritis: A prospective cohort study.
MedLine Citation:
PMID:  25106676     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: Changes in biomarkers for bone and cartilage in knee osteoarthritis (KOA) may reflect changes in tissue turnover induced by interventions. The aim of this study was to assess the effect on osteoarthritis biomarkers of an intensive weight loss intervention in obese KOA patients.
METHODS: 192 obese KOA patients followed a 16 weeks weight loss intervention (ClinicalTrials.gov : NCT00655941). Serum Cartilage Oligomeric Matrix Protein (sCOMP), Urine C-terminal telopeptide of collagen type II (uCTX-II) and type I (uCTX-I) were determined by ELISA at baseline and after 16 weeks. Patient-reported symptoms were assessed by the Knee Osteoarthritis Outcome Score (KOOS) Questionnaire without the sports and recreation score (KOOS-4). Change from baseline was analysed using ANCOVA adjusting for sex, age, and BMI. Bivariate associations were analysed using Spearman's test of rank correlation.
RESULTS: 175 patients completed the treatment and lost mean 13.4 (95% CI: 12.5 to 14.4) kg. sCOMP concentration decreased on average 1.1 (95%CI: -1.5 to -0.8) U/L with a correlation to weight loss (r=-0.17, p=0.028), but not to change in KOOS-4 (r=-0.13, p=0.091). uCTX-II increased significantly, mean 69 (95%CI: 31 to 106) ng/mmol creatinine, with no relation to weight loss (P=0.14). Change in uCTX-II was reversely related to change in KOOS-4 (r=-0.28, p=0.0003). uCTX-I increased, mean 67 (95%CI: 47 to 87) μg/mmol creatinine, and correlated to weight loss (r=0.22, p=0.0007), while not to KOOS-4 (P=0.93).
CONCLUSION: A rapid substantial weight loss in obese KOA patients was weakly, while significantly associated with a reduction in sCOMP, and increases in both uCTX-II and uCTX-I.
Authors:
Else Marie Bartels; Robin Christensen; Pia Christensen; Marius Henriksen; Alexandra Bennett; Henrik Gudbergsen; Mikael Boesen; Henning Bliddal
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-5
Journal Detail:
Title:  Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society     Volume:  -     ISSN:  1522-9653     ISO Abbreviation:  Osteoarthr. Cartil.     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9305697     Medline TA:  Osteoarthritis Cartilage     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014. Published by Elsevier Ltd.
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