| Effect of 150-mg vs 300-mg loading doses of clopidogrel on platelet function in Japanese patients undergoing coronary stent placement. | |
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MedLine Citation:
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PMID: 18654014 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The loading dose of ticlopidine is 500 mg in both the US and Europe and 200 mg in Japan. A lower loading dose of clopidogrel might achieve adequate platelet inhibition in Japanese patients. METHODS AND RESULTS: Platelet aggregation was serially measured at baseline, and 2, 4, 6, and 8 h after 150-mg (n=20) and 300-mg (n=20) clopidogrel loading. Platelets were stimulated with 5 and 20 micromol/L adenosine diphosphate (ADP) and aggregation was assessed by optical aggregometry. Pretreatment ADP-induced platelet aggregation in the 150-mg clopidogrel group did not differ from that of the 300-mg group. The administration of 300-mg clopidogrel loading dose resulted in lower platelet aggregation 2 h after the administration (5 micromol/L ADP: 53+/-9% vs 61+/-12%, p<0.05 and 20 micromol/L ADP: 61+/-10% vs 68+/-9%, p<0.05). A lower platelet aggregation induced with 20 micromol/L ADP was still observed 4 h after the 300-mg clopidogrel loading (58+/-10% vs 65+/-9%, p<0.05). CONCLUSIONS: The 150-mg clopidogrel loading does not achieve rapid platelet inhibition. The 300-mg loading dose should be used to suppress platelet function rapidly even in Japanese patients undergoing coronary stent placement. |
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Authors:
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Kenichi Fukushima; Yoshio Kobayashi; Hideki Kitahara; Yo Iwata; Takashi Nakayama; Nakabumi Kuroda; Masayuki Ooyama; Fumio Nomura; Issei Komuro |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article |
Journal Detail:
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Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 72 ISSN: 1346-9843 ISO Abbreviation: Circ. J. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-07-25 Completed Date: 2008-10-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
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Languages: eng Pagination: 1282-4 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Diphosphate
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diagnostic use Aged Angioplasty, Transluminal, Percutaneous Coronary* / adverse effects, instrumentation Asian Continental Ancestry Group Coronary Artery Disease / blood, ethnology, therapy* Coronary Thrombosis / blood, etiology, prevention & control* Dose-Response Relationship, Drug Female Humans Japan Male Middle Aged Platelet Aggregation / drug effects* Platelet Aggregation Inhibitors / administration & dosage* Platelet Function Tests Stents* Ticlopidine / administration & dosage, analogs & derivatives* Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Platelet Aggregation Inhibitors; 55142-85-3/Ticlopidine; 58-64-0/Adenosine Diphosphate; 90055-48-4/clopidogrel |
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