Document Detail

Effect of 12-O-tetradecanoylphorbol-13-acetate on selection of drug-resistant phenotypes in rodent cells.
MedLine Citation:
PMID:  6536598     Owner:  NLM     Status:  MEDLINE    
The effect of the tumour promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) on the selection of drug-resistant phenotypes in hamster and mouse cells has been studied. TPA increased considerably the incidence of methotrexate (MTX)-, N-(phosphonacetyl)-L-aspartate- and cadmium-resistant 3T6 and 3T3 mouse cell clones, but it had little effect on V79 and CHO hamster cells. The MTX-resistant V79 hamster cell clones, selected with or without TPA, lost their resistance within 15 cell cycles, however, 50% of the 3T6 mouse cell clones selected and maintained in the presence of TPA preserved their resistance for more than 15 cell cycles. A number of the MTX-resistant 3T6 clones overproduced dihydrofolate reductase enzyme; however, their frequency was lower among the clones selected in the presence of TPA.
F Bojan; A R Kinsella; M Fox
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  IARC scientific publications     Volume:  -     ISSN:  0300-5038     ISO Abbreviation:  IARC Sci. Publ.     Publication Date:  1984  
Date Detail:
Created Date:  1985-09-19     Completed Date:  1985-09-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8009542     Medline TA:  IARC Sci Publ     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  265-73     Citation Subset:  IM    
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MeSH Terms
Antimetabolites, Antineoplastic / pharmacology
Aspartic Acid / analogs & derivatives,  pharmacology
Cadmium / pharmacology
Cell Line
Cells, Cultured
Clone Cells
Drug Resistance*
Methotrexate / metabolism,  pharmacology
Phorbols / pharmacology*
Phosphonoacetic Acid / analogs & derivatives,  pharmacology
Tetradecanoylphorbol Acetate / pharmacology*
Tetrahydrofolate Dehydrogenase / metabolism
Reg. No./Substance:
0/Antimetabolites, Antineoplastic; 0/Phorbols; 16561-29-8/Tetradecanoylphorbol Acetate; 4408-78-0/Phosphonoacetic Acid; 51321-79-0/NSC 224131; 56-84-8/Aspartic Acid; 59-05-2/Methotrexate; 7440-43-9/Cadmium; EC Dehydrogenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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