Document Detail

Effect of the 100-g oral glucose tolerance test on fetal acid-base balance.
MedLine Citation:
PMID:  12673629     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Previous studies have shown that maternal hyperglycemia may lead to fetal hypoxia and acidosis. The aim of the present study was to examine the impact of an oral 100-g glucose tolerance test on the fetal acid-base balance at mid-gestation. METHODS: The study was conducted in healthy women who were scheduled for termination of pregnancy. The study group (n = 18) received an oral solution containing 100-g glucose and the control group (n = 18) received only water 1 h prior to termination of pregnancy. Termination of pregnancy was performed by fetal intracardiac injection of potassium chloride (KCl) and intraamniotic instillation of PGF2alpha. Acid-base variables were evaluated in the fetal blood and the amniotic fluid. RESULTS: The glucose levels differed significantly between the study group and the control group with regard to maternal blood (127 +/- 28 versus 69 +/- 11 mg/dL, p < 0.001), fetal blood (128 +/- 24 versus 71 +/- 17 mg/dL, p < 0.001) and amniotic fluid (39 +/- 13 versus 28 +/- 5 mg/dL, p < 0.006). A linear relationship was found between maternal, fetal and amniotic fluid levels of glucose after maternal glucose ingestion. No significant changes were observed in the acid-base balance variables (pH, base excess, bicarbonate, lactate) in the fetal blood and the amniotic fluid of the study and control groups. CONCLUSION: The 100-g oral glucose tolerance test has no adverse effect on the fetal acid-base balance when glucose levels reach a peak 1 h after the test in normal pregnancies.
Amir Weissman; Lior Lowenstein; Arie Drugan; Etan Z Zimmer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  23     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-04-03     Completed Date:  2003-11-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  England    
Other Details:
Languages:  eng     Pagination:  281-3     Citation Subset:  IM    
Copyright Information:
Copyright 2003 John Wiley & Sons, Ltd.
Department of Obstetrics and Gynecology, Rambam Medical Center, Haifa, Israel.
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MeSH Terms
Abortion, Legal
Acid-Base Equilibrium*
Amniotic Fluid / metabolism
Blood Glucose / analysis
Fetal Blood / chemistry
Fetus / drug effects*,  metabolism
Glucose / administration & dosage*,  analysis
Glucose Tolerance Test / methods*
Maternal-Fetal Exchange / physiology
Pregnancy / blood
Pregnancy Trimester, Second
Reg. No./Substance:
0/Blood Glucose; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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