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Effect Of A 10-Week Weight-Loss Camp On Fatty Liver Disease And Insulin Sensitivity In Obese Danish Children.
MedLine Citation:
PMID:  21760546     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES:: Childhood non-alcoholic fatty liver disease (NAFLD) associated with insulin resistance and obesity is a growing problem and increases risk of cirrhosis, type 2 diabetes, and cardiovascular complications. We examined the effects of a 10-week "weight-loss camp" residency in obese children on the prevalence and degree of NAFLD and insulin sensitivity with 12 month follow-up. METHODS:: At the camp, 117 obese Caucasian children (BMI 28.0 ± 3.6 kg/m, age 12.1 ± 1.3 years) exercised moderately for one hour per day and restricted their caloric intake to induce weight loss. NAFLD was diagnosed and graded using ultrasound and transaminasaemia. Insulin sensitivity and glucose tolerance was assessed using homeostasis model assessment (HOMA) and oral glucose tolerance test. We performed anthropometric measurements and determined body composition using bioimpedance. Data were collected at entry, after the 10 weeks at the camp, and 12 months after the camp ended in 71 of the 117 children. RESULTS:: The children showed an average weight loss of 7.1 ± 2.7 kg during the camp. At baseline, 43% had ultrasonographic liver steatosis, 50% elevated transaminases (>25 IU/L), and reduced insulin sensitivity. These abnormalities were mutually related and improved significantly during the camp (P < 0.05 or less). Liver fat improvement was sustained at 12 month. At the 12-month follow up, 17/71 (24%) children maintained the body weight. DISCUSSION:: This short-term diet and exercise program induced weight loss, markedly improved all aspects of the threatening condition of NAFLD and reduced insulin sensitivity in childhood obesity; 24% of the children maintained weight loss at least until the 12-month follow-up.
Authors:
Henning Grønbæk; Aksel Lange; Niels H Birkebæk; Peter Holland-Fischer; Jan Solvig; Arne Hørlyck; Kurt Kristensen; Søren Rittig; Hendrik Vilstrup
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-12
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  -     ISSN:  1536-4801     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
*Department of Medicine V (Hepatology and Gastroenterology) †Department of Pediatrics ‡Department of Radiology, Aarhus University Hospital, Aarhus, Denmark.
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