| Effect of 1% sodium hyaluronate (Healon) on a nonregenerating (feline) corneal endothelium. | |
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MedLine Citation:
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PMID: 3531081 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A series of experiments were performed to investigate the effect of 1% sodium hyaluronate (Healon) on the nonregenerating corneal endothelium of the cat. Aqueous humor replacement with 1% sodium hyaluronate resulted in mild, transient elevations of intraocular pressure compared to eyes that were injected with balanced salt solution. Sodium hyaluronate 1% protected the feline endothelium against cell loss incurred by contact with hyaluronate-coated intraocular lenses compared to endothelial contact with lenses that were not coated with sodium hyaluronate. The use of intraoperative 1% sodium hyaluronate, however, did not protect against endothelial cell loss incurred by penetrating keratoplasty or prevent subsequent skin graft-induced corneal homograft rejections. Homograft rejections were milder, however, in some eyes that received grafts coated with 1% sodium hyaluronate. Image analysis of photographs of trypan blue- and alizarin red-stained corneal buttons after trephining, stretching of Descemet's membrane, rubbing against iris-lens preparations, or immediately after penetrating keratoplasty demonstrated that the stretching of the posterior cornea is an important cause of endothelial damage that would not be protected against by a viscoelastic coating. |
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Authors:
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C F Bahn; R Grosserode; D C Musch; J Feder; R F Meyer; D K MacCallum; J H Lillie; N M Rich |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Investigative ophthalmology & visual science Volume: 27 ISSN: 0146-0404 ISO Abbreviation: Invest. Ophthalmol. Vis. Sci. Publication Date: 1986 Oct |
Date Detail:
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Created Date: 1986-11-13 Completed Date: 1986-11-13 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7703701 Medline TA: Invest Ophthalmol Vis Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1485-94 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aqueous Humor Cats Cornea / drug effects*, injuries Corneal Transplantation Endothelium / drug effects Hyaluronic Acid / pharmacology* Lenses, Intraocular / adverse effects Postoperative Complications / prevention & control |
| Grant Support | |
ID/Acronym/Agency:
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EY 05576/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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9004-61-9/Hyaluronic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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