Document Detail

Effect of 1-desamino-8-D-arginine vasopressin (DDAVP) on vasopressin release and blood pressure during hemorrhage.
MedLine Citation:
PMID:  1478192     Owner:  NLM     Status:  MEDLINE    
Whether or not 1-desamino-8-D-arginine-vasopressin (DDAVP) reduces blood pressure or affects the release of arginine vasopressin (AVP) and renin is controversial, although evidence suggests AVP and renin are important in maintaining blood pressure during hemorrhage. We therefore investigated the effect of DDAVP on endogenous release of AVP and renin and on blood pressure during hemorrhage in dogs. In the control group the hemorrhage was performed at a rate of 0.4 for 40 min from the femoral artery. The plasma AVP concentration and renin activity (PRA) increased progressively in response to the hemorrhage, from 7.5 +/- 0.5 to 40.3 +/- 7.3, and from 11.8 +/- 1.5 to 20.5 +/- 4.2, respectively, while blood pressure decreased slightly. In the DDAVP group, intravenous infusion of DDAVP (2.5 for 40 min) and hemorrhage were simultaneously performed. The plasma DDAVP concentration increased progressively to 218 +/- 21.0 There was no significant difference, however, between the control and DDAVP groups in the response of AVP, PRA and blood pressure. The results suggested that DDAVP may not affect the release of AVP and renin or blood pressure during hemorrhage.
K Shimizu; A Nakao
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Endocrinologia japonica     Volume:  39     ISSN:  0013-7219     ISO Abbreviation:  Endocrinol. Jpn.     Publication Date:  1992 Oct 
Date Detail:
Created Date:  1993-02-09     Completed Date:  1993-02-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376546     Medline TA:  Endocrinol Jpn     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  517-23     Citation Subset:  IM    
Department of Internal Medicine, Tokyo Rosai (Occupational Diseases and Injuries) Hospital, Japan.
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MeSH Terms
Aldosterone / blood
Analysis of Variance
Arginine Vasopressin / secretion*
Blood Pressure / drug effects*
Deamino Arginine Vasopressin / pharmacology*
Heart Rate
Hemorrhage / drug therapy*,  physiopathology*
Infusions, Intravenous
Kidney / metabolism
Pituitary Gland, Posterior / drug effects,  secretion
Renin / blood
Time Factors
Reg. No./Substance:
113-79-1/Arginine Vasopressin; 16679-58-6/Deamino Arginine Vasopressin; 52-39-1/Aldosterone; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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