| Effect of 1-desamino-8-D-arginine vasopressin (DDAVP) on vasopressin release and blood pressure during hemorrhage. | |
| | |
MedLine Citation:
|
PMID: 1478192 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Whether or not 1-desamino-8-D-arginine-vasopressin (DDAVP) reduces blood pressure or affects the release of arginine vasopressin (AVP) and renin is controversial, although evidence suggests AVP and renin are important in maintaining blood pressure during hemorrhage. We therefore investigated the effect of DDAVP on endogenous release of AVP and renin and on blood pressure during hemorrhage in dogs. In the control group the hemorrhage was performed at a rate of 0.4 ml.kg-1.min-1 for 40 min from the femoral artery. The plasma AVP concentration and renin activity (PRA) increased progressively in response to the hemorrhage, from 7.5 +/- 0.5 to 40.3 +/- 7.3 pg.ml-1, and from 11.8 +/- 1.5 to 20.5 +/- 4.2 ng.ml-1.h-1, respectively, while blood pressure decreased slightly. In the DDAVP group, intravenous infusion of DDAVP (2.5 ng.kg-1.min-1 for 40 min) and hemorrhage were simultaneously performed. The plasma DDAVP concentration increased progressively to 218 +/- 21.0 pg.ml-1. There was no significant difference, however, between the control and DDAVP groups in the response of AVP, PRA and blood pressure. The results suggested that DDAVP may not affect the release of AVP and renin or blood pressure during hemorrhage. |
| | |
Authors:
|
K Shimizu; A Nakao |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Endocrinologia japonica Volume: 39 ISSN: 0013-7219 ISO Abbreviation: Endocrinol. Jpn. Publication Date: 1992 Oct |
Date Detail:
|
Created Date: 1993-02-09 Completed Date: 1993-02-09 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0376546 Medline TA: Endocrinol Jpn Country: JAPAN |
Other Details:
|
Languages: eng Pagination: 517-23 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine, Tokyo Rosai (Occupational Diseases and Injuries) Hospital, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aldosterone
/
blood Analysis of Variance Animals Arginine Vasopressin / secretion* Blood Pressure / drug effects* Deamino Arginine Vasopressin / pharmacology* Dogs Heart Rate Hemorrhage / drug therapy*, physiopathology* Infusions, Intravenous Kidney / metabolism Male Pituitary Gland, Posterior / drug effects, secretion Renin / blood Time Factors |
| Chemical | |
Reg. No./Substance:
|
113-79-1/Arginine Vasopressin; 16679-58-6/Deamino Arginine Vasopressin; 52-39-1/Aldosterone; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of age, sex and renal function on urinary insulin-like growth factor I (IGF-I) levels in adu...
Next Document: Chemical systems for delivery of antiepileptic drugs to the central nervous system.