Document Detail


Effecacy of Cyclosporine A-nanoparticles Emulsion Combined with Stem Cell Transplantation Therapy for Acute Myocardial Infarction.
MedLine Citation:
PMID:  23987487     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
<p>Objective To evaluate the efficacy of cyclosporine A-nanoparticles emulsion(CsA-NP)combined with adipose tissue-derived stem cells(ASCs)transplantation therapy for acute myocardial infarction(AMI)in a miniswine model.Methods CsA-NP emulsion was prepared by the high-pressure homogenization method.Models were performed by coronary angioplasty for percutaneous balloon occlusion of left anterior descending artery(LAD).A total of 17 miniswines survived after AMI were divided into four groups:control group(n=5),CsA-NP group(n=4),ASCs group(n=4),and CsA-NP+ASCs group(n=4).ASCs or saline were delivered by intracoronary injection one week after AMI.Before cell transplantation and 8 weeks after cell transplantation,delayed-enhanced magnetic resonance imaging(DE-MRI)was performed to evaluate cardiac function and viability.The infarcted myocardium and implanted cells were histologically studied.Results Eight weeks after treatment,the left ventricular ejection fraction(LVEF)significantly increased in the CsA-NP+ASCs group when compared with the ASCs group[(53.6±2.4)% vs.(48.3±1.8)%,P<0.05];meanwhile,the infarct size significantly decreased[(6.2±1.7)cm(3) vs.(7.5±0.6)cm(3),P<0.05]and the thickness of the ventricular wall significantly increased(P<0.05).Histology showed that the number of surviving cells increased nearly by three times in the CsA-NP+ASCs group,and the expressions of the cardiomyocyte specific markers(cTnT and α-actin)were detected.Histological samples also showed that CsA-NP+ASCs group reduced fibrotic tissue,and down-regulated the activation of Caspase-3.Conclusion The CsA-NP+ASCs combination therapy can enhance the viability of ASCs by improving LVEF and preventing LV expansion,which may be explained that CsA-NP has the anti-apoptotic effect and can promote the survivals and proliferation of ASCs.</p>
Authors:
Yin Qiao-Xiang; Wang Heng; Pei Zhi-Yong; Zhao Yu-Sheng
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae     Volume:  35     ISSN:  1000-503X     ISO Abbreviation:  Zhongguo Yi Xue Ke Xue Yuan Xue Bao     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-08-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006230     Medline TA:  Zhongguo Yi Xue Ke Xue Yuan Xue Bao     Country:  China    
Other Details:
Languages:  eng     Pagination:  404-10     Citation Subset:  IM    
Affiliation:
Department of Geriatric Cardiology,Chinese General Hospital of Air Force,Beijing 100142,China.
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