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Efalizumab-induced severe thrombocytopenia can be resolved.
MedLine Citation:
PMID:  19707471     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Efalizumab is a monoclonal a humanized recombinant IgG1 monoclonal antibody which targets the CD11a, the alpha-subunit of LFA-1 (lymphocyte function-associated antigen-1). It acts by blocking the T-lymphocyte pathogenetic mechanisms of psoriasis. Thrombocytopenia is an adverse event that occurs during therapy. Thrombocytopenia can be mild and can occur quite early during treatment, together with leukocytosis. Both adverse events tend to normalize with ongoing therapy, or, in cases worsening, with therapy suspension. There have been multiple reports of thrombocytopenia associated with efalizumab therapy for the treatment of psoriasis. The general recommendation is to check platelet counts monthly for the first 3 months of efalizumab therapy, then every 3 months for the duration of therapy. According to our experience on a wide range of patients, it is useful to check platelets every month for the first 6 months of therapy. We report a case of efalizumab-associated thrombocytopenia that occurred after 16 weeks of therapy together with clinical worsening of skin lesions. The peculiarity of our case is the absence of signs and symptoms linked to thrombocytopenia and the quick return to normal platelet count without corticosteroid therapy.
Authors:
Francesca Prignano; F Zanieri; S Mokhtarzadeh; T Lotti
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biologics : targets & therapy     Volume:  2     ISSN:  1177-5475     ISO Abbreviation:  Biologics     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2009-08-26     Completed Date:  2011-07-14     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  101321511     Medline TA:  Biologics     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  923-7     Citation Subset:  -    
Affiliation:
University Unit of Dermatology and Physiotherapy, School of Medicine, University of Florence, Florence, Italy.
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