Document Detail


Educational paper: Retinopathy of prematurity.
MedLine Citation:
PMID:  22052209     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Retinopathy of prematurity (ROP) is a proliferative retinal vascular disease affecting the premature infant with an incompletely vascularized retina. The spectrum of ophthalmological findings in ROP exists from minimal sequelae, which do not affect vision, to bilateral retinal detachment and total blindness. With the increased survival of very small infants, retinopathy of prematurity has become one of the leading causes of childhood blindness. Over the past two decades, major advances have been made in understanding the pathogenesis of ROP, to a large extent as a result of changes in clinical risk factors (oxygen and non-oxygen related) and characteristics observed in ROP cases. This article provides a literature review on the evolution in clinical characteristics, classification and treatment modalities and indications of ROP. Special attention is hereby paid to the neonatal factors influencing the development of ROP and to the necessity for everyone caring for premature babies to have a well-defined screening and treatment protocol for ROP. Such screening protocol needs to be based on a unit-specific ROP risk profile and, consequently, may vary between different European regions. Conclusion: Retinopathy of prematurity is an important cause of ocular morbidity and blindness in children. With better understanding of the pathogenesis, screening and treatment guidelines have changed over time and are unit specific.
Authors:
Ingele Casteels; Catherine Cassiman; Joachim Van Calster; Karel Allegaert
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2011-11-04
Journal Detail:
Title:  European journal of pediatrics     Volume:  171     ISSN:  1432-1076     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-22     Completed Date:  2012-10-17     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  887-93     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium. Ingele.Casteels@uzleuven.be
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MeSH Terms
Descriptor/Qualifier:
Angiogenesis Inhibitors / therapeutic use
Antibodies, Monoclonal, Humanized / therapeutic use
Cryotherapy
Humans
Infant, Newborn
Infant, Premature
Lasers, Semiconductor / therapeutic use
Neonatal Screening
Retinopathy of Prematurity* / classification,  diagnosis,  etiology,  therapy
Risk Factors
Chemical
Reg. No./Substance:
0/Angiogenesis Inhibitors; 0/Antibodies, Monoclonal, Humanized; 2S9ZZM9Q9V/bevacizumab

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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